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Single- versus multiple-sampling strategy for blood cultures in the diagnosis of infective endocarditis: the prospective multicenter UniEndo study

dc.rights.licenseopenen_US
dc.contributor.authorGOEHRINGER, Francois
dc.contributor.authorSOUDANT, Marc
dc.contributor.authorALAUZET, Corentine
dc.contributor.authorSELTON-SUTY, Christine
dc.contributor.authorAGRINIER, Nelly
dc.contributor.authorVIRION, Jean-Marc
dc.contributor.authorLEFEVRE, Benjamin
dc.contributor.authorAISSA, Nejla
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorALLA, Francois
dc.contributor.authorRUCH, Yvon
dc.contributor.authorN'GUYEN, Yohan
dc.contributor.authorPIROTH, Lionel
dc.contributor.authorBOUILLER, Kevin
dc.contributor.authorROYER, Pierre-Yves
dc.contributor.authorLE MOING, Vincent
dc.contributor.authorHOEN, Bruno
dc.contributor.authorDUVAL, Xavier
dc.date.accessioned2025-06-05T13:23:16Z
dc.date.available2025-06-05T13:23:16Z
dc.date.issued2025-04-03
dc.identifier.issn1537-6591en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206821
dc.description.abstractEnBACKGROUND: Single-sampling strategy (SSS) for blood cultures (BC) has not been evaluated in infective endocarditis (IE). We assessed the diagnostic performance of SSS vs conventional multi-sampling strategy (MSS) in IE diagnosis. METHODS: Patients suspected of IE were prospectively enrolled in 8 tertiary-care centers. Five BC bottle pairs were sampled from each patient. Pairs 1, 2 and 3 were sampled simultaneously, followed by 2 additional separate pairs (4 and 5) sampled more than one hour later. Pairs 1, 2, and 3 emulated SSS and pairs 1, 4, and 5 emulated MSS. The sensitivity and specificity of the major microbiologic criterion of the 2015-ESC IE diagnostic criteria, based on the SSS and MSS BC results, were calculated using the endocarditis team's diagnosis as the gold standard. RESULTS: An IE was diagnosed in 101 (39.4%) of the 256 patients enrolled. Sensitivity rates of SSS and MSS were 50.5% (95%CI [40.7-60.2]) and 45.5% (95%CI [35.8-55.3]), respectively (p = 0.063), while specificity rates were 94.8% (95%CI [91.4-98.3]) and 95.5% (95%CI [92.2-98.8]), respectively (p = 1). In IE patients, SSS as compared to MSS accurately upgraded the diagnosis from possible to definite IE in one patient and downgraded it in none. CONCLUSION: Using SSS to define the major microbiologic criterion was as sensitive and specific as using MSS for diagnosing IE. Using SSS instead of MSS BC results did not lead to erroneous changes in diagnostic class according to the 2015 ESC criteria. Consequently, SSS may be regarded as standard practice for IE diagnosis.
dc.language.isoENen_US
dc.subject.enInfective Endocarditis
dc.subject.enBlood Culture
dc.subject.enBlood Sampling
dc.subject.enDiagnostic Strategy
dc.title.enSingle- versus multiple-sampling strategy for blood cultures in the diagnosis of infective endocarditis: the prospective multicenter UniEndo study
dc.title.alternativeClin Infect Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/cid/ciaf163en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40176205en_US
bordeaux.journalClinical Infectious Diseasesen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPHARES_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical%20Infectious%20Diseases&rft.date=2025-04-03&rft.eissn=1537-6591&rft.issn=1537-6591&rft.au=GOEHRINGER,%20Francois&SOUDANT,%20Marc&ALAUZET,%20Corentine&SELTON-SUTY,%20Christine&AGRINIER,%20Nelly&rft.genre=article


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