Case report: Complete restoration of the HPA axis function in Cushing’s disease with drug treatment
| dc.rights.license | open | en_US |
| hal.structure.identifier | CHU de Bordeaux Pellegrin [Bordeaux] | |
| dc.contributor.author | NGUYEN, Joanne Thanh-Tâm | |
| hal.structure.identifier | CHU de Bordeaux Pellegrin [Bordeaux] | |
| dc.contributor.author | FERRIÈRE, Amandine | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | TABARIN, Antoine | |
| dc.date.accessioned | 2025-05-27T08:48:31Z | |
| dc.date.available | 2025-05-27T08:48:31Z | |
| dc.date.issued | 2024-02-08 | |
| dc.identifier.issn | 1664-2392 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/206740 | |
| dc.description.abstractEn | This report describes a rare case of a 20-year-old man with an ACTH- and prolactin-secreting invasive pituitary macroadenoma causing hyperprolactinemia and Cushing’s disease. He was later found to have an AIP mutation. Treatment with cabergoline (1.5 mg weekly) normalized prolactin concentrations and induced a major shrinkage of the adenoma. Not only was urinary free cortisol normalized for more than 14 years, but also the treatment induced normal hypothalamo-pituitary-adrenal (HPA) axis function as illustrated by the reappearance of a normal cortisol/ACTH circadian rhythm, cortisol suppression to dexamethasone, and disappearance of the excessive and aberrant responses to CRH and desmopressin, respectively. This case is the first description of complete restoration of the physiological characteristics of the HPA axis by a medication during the treatment of Cushing’s disease. Although exceptional, it illustrates that drugs targeting the pituitary adenoma can bring true complete remission of Cushing’s disease. Copyright © 2024 Nguyen, Ferrière and Tabarin. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Cabergoline | |
| dc.subject.en | Pituitary macroadenoma | |
| dc.subject.en | Prolactinoma | |
| dc.subject.en | Remission | |
| dc.subject.en | AIP mutation | |
| dc.subject.en | Cushing’s disease | |
| dc.title.en | Case report: Complete restoration of the HPA axis function in Cushing’s disease with drug treatment | |
| dc.title.alternative | Front Endocrinol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/fendo.2024.1337741 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 38390203 | en_US |
| bordeaux.journal | Frontiers in Endocrinology | en_US |
| bordeaux.volume | 15 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Physiopathologie de l'équilibre énergétique et obésité | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-05086307 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-05-27T08:48:33Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Endocrinology&rft.date=2024-02-08&rft.volume=15&rft.eissn=1664-2392&rft.issn=1664-2392&rft.au=NGUYEN,%20Joanne%20Thanh-T%C3%A2m&FERRI%C3%88RE,%20Amandine&TABARIN,%20Antoine&rft.genre=article |