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Case report: Complete restoration of the HPA axis function in Cushing’s disease with drug treatment
TABARIN, Antoine
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
TABARIN, Antoine
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
< Leer menos
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
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EN
Article de revue
Este ítem está publicado en
Frontiers in Endocrinology. 2024-02-08, vol. 15
Resumen en inglés
This report describes a rare case of a 20-year-old man with an ACTH- and prolactin-secreting invasive pituitary macroadenoma causing hyperprolactinemia and Cushing’s disease. He was later found to have an AIP mutation. ...Leer más >
This report describes a rare case of a 20-year-old man with an ACTH- and prolactin-secreting invasive pituitary macroadenoma causing hyperprolactinemia and Cushing’s disease. He was later found to have an AIP mutation. Treatment with cabergoline (1.5 mg weekly) normalized prolactin concentrations and induced a major shrinkage of the adenoma. Not only was urinary free cortisol normalized for more than 14 years, but also the treatment induced normal hypothalamo-pituitary-adrenal (HPA) axis function as illustrated by the reappearance of a normal cortisol/ACTH circadian rhythm, cortisol suppression to dexamethasone, and disappearance of the excessive and aberrant responses to CRH and desmopressin, respectively. This case is the first description of complete restoration of the physiological characteristics of the HPA axis by a medication during the treatment of Cushing’s disease. Although exceptional, it illustrates that drugs targeting the pituitary adenoma can bring true complete remission of Cushing’s disease. Copyright © 2024 Nguyen, Ferrière and Tabarin.< Leer menos
Palabras clave en inglés
Cabergoline
Pituitary macroadenoma
Prolactinoma
Remission
AIP mutation
Cushing’s disease
Centros de investigación