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dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBEYER, Frauke
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorTSUCHIDA, Ami
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSOUMARE, Aicha
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAJULA, Hema Sekhar Reddy
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMISHRA, Aniket
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorCRIVELLO, Fabrice
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST LIMA, Cecile
dc.contributor.authorLOEFFLER, Markus
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
dc.contributor.authorAMOUYEL, Philippe
dc.contributor.authorVILLRINGER, Arno
dc.contributor.authorSCHOLZ, Markus
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorJACQMIN-GADDA, Helene
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorJOLIOT, Marc
dc.contributor.authorWITTE, A Veronica
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.date.accessioned2025-05-21T12:01:44Z
dc.date.available2025-05-21T12:01:44Z
dc.date.issued2025-04-01
dc.identifier.issn1552-5279en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206669
dc.description.abstractEnINTRODUCTION: White matter hyperintensities (WMHs), a major cerebral small vessel disease (cSVD) marker, may arise from different pathologies depending on their location. We explored clinical and genetic correlates of agnostically derived spatial WMH patterns in two longitudinal population-based cohorts (Three-City Study [3C]-Dijon, LIFE-Adult). METHODS: We derived seven WMH spatial patterns using Bullseye segmentation in 2878 individuals aged 65+ and explored their associations with vascular and genetic risk factors, cognitive performance, dementia and stroke incidence. RESULTS: WMHs in the frontoparietal and anterior periventricular region were associated with blood pressure traits, WMH genetic risk score (GRS), baseline and decline in general cognitive performance, incident all-cause dementia, and ischemic stroke. Juxtacortical-deep occipital WMHs were not associated with vascular risk factors and WMH GRS, but with incident all-cause dementia and intracerebral hemorrhage. DISCUSSION: Accounting for WMH spatial distribution is key to deciphering mechanisms underlying cSVD subtypes, an essential step towards personalized therapeutic approaches. HIGHLIGHTS: We studied spatial patterns of WMHs in 2878 participants. Blood pressure was associated with frontoparietal and anterior PV WMHs. Anterior PV WMHs predicted dementia and stroke risk. Juxtacortical-deep occipital WMH burden was not associated with blood pressure or WMH genetic risk. Juxtacortical-deep occipital WMH burden predicted dementia and intracerebral hemorrhage.
dc.description.sponsorshipStopping cognitive decline and dementia by fighting covert cerebral small vessel diseaseen_US
dc.description.sponsorshipVaincre les maladies vasculaires cérébrales par un nouveau paradigme de prévention de précision et d'innovation thérapeutique - ANR-23-IAHU-0001en_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enDementia
dc.subject.enGenetics
dc.subject.enSpatial Patterns
dc.subject.enStroke
dc.subject.enVascular Risk
dc.subject.enWhite Matter Hyperintensities
dc.title.enWhite matter hyperintensity spatial patterns: Risk factors and clinical correlates
dc.title.alternativeAlzheimers Dementen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/alz.70053en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40189793en_US
bordeaux.journalAlzheimer's & Dementia : the Journal of the Alzheimer's Associationen_US
bordeaux.pagee70053en_US
bordeaux.volume21en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPHARES_BPHen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDCaisse nationale de solidarité pour l'autonomieen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDFondation Claude Pompidouen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDHorizon 2020en_US
hal.identifierhal-05077331
hal.version1
hal.date.transferred2025-05-21T12:01:49Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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