Rethinking the role of microglia in obesity
| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | CUTUGNO, Giulia | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | KYRIAKIDOU, Evangelia | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | NADJAR, Agnes | |
| dc.date.accessioned | 2025-05-19T10:32:04Z | |
| dc.date.available | 2025-05-19T10:32:04Z | |
| dc.date.issued | 2024-08-01 | |
| dc.identifier.issn | 0028-3908 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/206650 | |
| dc.description.abstractEn | Microglia are the macrophages of the central nervous system (CNS), implying their role in maintaining brain homeostasis. To achieve this, these cells are sensitive to a plethora of endogenous and exogenous signals, such as neuronal activity, cellular debris, hormones, and pathological patterns, among many others. More recent research suggests that microglia are highly responsive to nutrients and dietary variations. In this context, numerous studies have demonstrated their significant role in the development of obesity under calorie surfeit. Because many reviews already exist on this topic, we have chosen to present the state of our reflections on various concepts put forth in the literature, bringing a new perspective whenever possible. Our literature review focuses on studies conducted in the arcuate nucleus of the hypothalamus, a key structure in the control of food intake. Specifically, we present the recent data available on the modifications of microglial energy metabolism following the consumption of an obesogenic diet and their consequences on hypothalamic neuron activity. We also highlight the studies unraveling the mechanisms underlying obesity-related sexual dimorphism. The review concludes with a list of questions that remain to be addressed in the field to achieve a comprehensive understanding of the role of microglia in the regulation of body energy metabolism. © 2024 The Authors | |
| dc.description.sponsorship | Rôle des altérations bioénergétiques microgliales précoces dans l'hétérogénéité des phénotypes obèses dépendante du sexe - ANR-23-CE14-0076 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Humans | |
| dc.subject.en | Animals | |
| dc.subject.en | Sex Difference | |
| dc.subject.en | Animal | |
| dc.subject.en | Pathology | |
| dc.subject.en | Pathophysiology | |
| dc.subject.en | Metabolism | |
| dc.subject.en | Obesity | |
| dc.subject.en | Physiology | |
| dc.subject.en | Food Intake | |
| dc.subject.en | Mammalian Target Of Rapamycin | |
| dc.subject.en | Energy Metabolism | |
| dc.subject.en | Metabolic Regulation | |
| dc.subject.en | Obesogenic Diet | |
| dc.subject.en | Hypothalamus | |
| dc.subject.en | Neuromodulation | |
| dc.subject.en | Energy Metabolism | |
| dc.subject.en | Microglia | |
| dc.subject.en | Arcuate Nucleus | |
| dc.subject.en | Cell Interaction | |
| dc.subject.en | Arcuate Nucleus Of Hypothalamus | |
| dc.subject.en | Macrophage Function | |
| dc.subject.en | Mtor Signaling | |
| dc.subject.en | Nerve Function | |
| dc.subject.en | Sex Characteristics | |
| dc.subject.en | Sexual Characteristics | |
| dc.title.en | Rethinking the role of microglia in obesity | |
| dc.title.alternative | Neuropharmacology | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.neuropharm.2024.109951 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 38615749 | en_US |
| bordeaux.journal | Neuropharmacology | en_US |
| bordeaux.volume | 253 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Physiopathologie de l'équilibre énergétique et obésité | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-05073226 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-05-19T10:32:07Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | CC BY | en_US |
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