Associations between agricultural use of pyrethroid insecticides and asthma: AGRICAN cohort results
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BALDI, Isabelle | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DE GRAAF, Lucie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BUREAU, Mathilde | |
| dc.contributor.author | TUAL, Severine | |
| dc.contributor.author | DOUWES, Jeroen | |
| dc.contributor.author | LEBAILLY, Pierre | |
| dc.date.accessioned | 2025-05-16T07:52:00Z | |
| dc.date.available | 2025-05-16T07:52:00Z | |
| dc.date.issued | 2025-04-10 | |
| dc.identifier.issn | 0013-9351 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/206639 | |
| dc.description.abstractEn | RATIONALE: Following the withdrawal of organochlorines and organophosphates, pyrethroids have become the most used insecticides in both agricultural and domestic settings. OBJECTIVES: We analyzed data from the French AGRICAN agricultural cohort to assess associations of occupational pyrethroid exposures and allergic/non-allergic asthma. METHODS: At enrollment, asthma diagnosed by a doctor was reported by 11 815 participants (7028 classified as non-allergic and 4458 as allergic based on the presence of eczema and/or hay fever). Individual exposures to 17 pyrethroids were defined in 124 992 participants, based on a combination of the history of pesticide treatment of 11 crops (grassland, vineyard, wheat/barley, corn, field peas, potatoes, tobacco, beets, sunflower, rape, fruits) and a crop-exposure matrix. MEASUREMENTS AND MAIN RESULTS: In men, no association was observed for any of the pyrethroids regardless of asthma phenotype. In contrast, in ever-exposed women, asthma risk was increased with use of any pyrethroid, both for allergic (+80 %) and non-allergic asthma (+40 %). Highest increases were observed for allergic asthma with fenpropathrin (OR = 2.00; 95 %CI:1.38-2.90), tralomethrin (OR = 1.81; 95 %CI:1.28-2.56), fenvalerate (OR = 1.81; 95 %CI:1.38-2.38), permethrin (OR = 1.78; 95 %CI:1.26-2.50) and deltamethrin (OR = 1.76; 95 %CI:1.35-2.29). Stratified analyses on women who reported living on a farm in early life showed stronger associations for non-allergic asthma. For women who reported early life living on vineyards associations with pyrethroids were stronger for both allergic and non-allergic asthma. Associations for women who lived on cattle farms were reduced for some pyrethroids. CONCLUSION: Occupational pyrethroid exposure was positively associated with both allergic and non-allergic asthma in women but not in men. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Agricultural exposure | |
| dc.subject.en | Allergy | |
| dc.subject.en | Asthma | |
| dc.subject.en | Pesticides | |
| dc.subject.en | Pyrethroids | |
| dc.title.en | Associations between agricultural use of pyrethroid insecticides and asthma: AGRICAN cohort results | |
| dc.title.alternative | Environ Res | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.envres.2025.121583 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 40220893 | en_US |
| bordeaux.journal | Environmental Research | en_US |
| bordeaux.page | 121583 | en_US |
| bordeaux.volume | 277 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | EPICENE_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-05070206 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-05-16T07:52:02Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Research&rft.date=2025-04-10&rft.volume=277&rft.spage=121583&rft.epage=121583&rft.eissn=0013-9351&rft.issn=0013-9351&rft.au=BALDI,%20Isabelle&DE%20GRAAF,%20Lucie&BUREAU,%20Mathilde&TUAL,%20Severine&DOUWES,%20Jeroen&rft.genre=article |
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