Silanization Strategies for Tailoring Peptide Functionalization on Silicon Surfaces: Implications for Enhancing Stem Cell Adhesion
| dc.rights.license | open | en_US |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | KOSOVARI, Melissa | |
| dc.contributor.author | BUFFETEAU, Thierry | |
| dc.contributor.author | THOMAS, Laurent | |
| dc.contributor.author | GUAY-BEGIN, Andree-Anne | |
| dc.contributor.author | VELLUTINI, Luc | |
| dc.contributor.author | MCGETTRICK, James | |
| dc.contributor.author | LAROCHE, Gaetan | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | DURRIEU, Marie-Christine | |
| dc.date.accessioned | 2025-04-30T11:55:15Z | |
| dc.date.available | 2025-04-30T11:55:15Z | |
| dc.date.issued | 2024-06-04 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/206498 | |
| dc.description.abstractEn | Biomaterial surface engineering and the integration of cell-adhesive ligands are crucial in biological research and biotechnological applications. The interplay between cells and their microenvironment, influenced by chemical and physical cues, impacts cellular behavior. Surface modification of biomaterials profoundly affects cellular responses, especially at the cell-surface interface. This work focuses on enhancing cellular activities through material manipulation, emphasizing silanization for further functionalization with bioactive molecules such as RGD peptides to improve cell adhesion. The grafting of three distinct silanes onto silicon wafers using both spin coating and immersion methods was investigated. This study sheds light on the effects of different alkyl chain lengths and protecting groups on cellular behavior, providing valuable insights into optimizing silane-based self-assembled monolayers (SAMs) before peptide or protein grafting for the first time. Specifically, it challenges the common use of APTES molecules in this context. These findings advance our understanding of surface modification strategies, paving the way for tailoring biomaterial surfaces to modulate the cellular behavior for diverse biotechnological applications. | |
| dc.description.sponsorship | Conception de surfaces bioinspirées avec des propriétés mécaniques et de bioactivité contrôlées pour la synthèse de plateforme in vitro de culture cellulaire - ANR-21-CE06-0031 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Biomaterial surface engineering | |
| dc.subject.en | Silanization | |
| dc.subject.en | Integrin-based ligands | |
| dc.subject.en | Surface functionalization | |
| dc.subject.en | Cell adhesion | |
| dc.title.en | Silanization Strategies for Tailoring Peptide Functionalization on Silicon Surfaces: Implications for Enhancing Stem Cell Adhesion | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1021/acsami.4c03727 | en_US |
| dc.subject.hal | Chimie/Matériaux | en_US |
| bordeaux.journal | ACS Applied Materials & Interfaces | en_US |
| bordeaux.page | 29770-29782 | en_US |
| bordeaux.volume | 16 | en_US |
| bordeaux.hal.laboratories | CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248 | en_US |
| bordeaux.issue | 23 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
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