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dc.rights.licenseopenen_US
dc.contributor.authorKUCZYNSKI-NOYAU, Laura
dc.contributor.authorKARMANN, Sixtine
dc.contributor.authorALBERTON, Paolo
dc.contributor.authorMARTINEZ-CORRAL, Ines
dc.contributor.authorNAMPOOTHIRI, Sreekala
dc.contributor.authorSAUVÉ, Florent
dc.contributor.authorLHOMME, Tori
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorQUARTA, Carmelo
dc.contributor.authorAPTE, Suneel
dc.contributor.authorBOURET, Sébastien
dc.contributor.authorASZODI, Attila
dc.contributor.authorRASIKA, Sowmyalakshmi
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCIOFI, Philippe
dc.contributor.authorDAM, Julie
dc.contributor.authorPRÉVOT, Vincent
dc.contributor.authorMATTOT, Virginie
dc.date.accessioned2025-04-30T07:28:57Z
dc.date.available2025-04-30T07:28:57Z
dc.date.issued2024-08-07
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206494
dc.description.abstractEnThe hypothalamic arcuate nucleus (ARH) contains neurons vital for maintaining energy homeostasis that sense and respond to changes in blood-borne metabolic hormones. Despite its juxtaposition to the median eminence (ME), a circumventricular organ lacking a blood-brain barrier and thus exposed to circulating molecules, only a few ventral ARH neurons perceive these extravasating metabolic signals due to a poorly understood ME/ARH diffusion barrier. Here, we show in male mice that aggrecan, a perineural-net proteoglycan deposited by orexigenic ARH neurons, creates a peculiar ventrodorsal diffusion gradient. Fasting enhances aggrecan deposition more dorsally, reinforcing the diffusion barrier, particularly around neurons adjacent to fenestrated capillary loops that enter the ARH. The disruption of aggrecan deposits results in unregulated diffusion of blood-borne molecules into the ARH and impairs food intake. Our findings reveal the molecular nature and plasticity of the ME/ARH diffusion barrier, and indicate its physiological role in hypothalamic metabolic hormone sensing. © The Author(s) 2024.
dc.description.sponsorshipLe rôle physio-pathologique d'une " barrière de diffusion latérale " inexplorée dans le dialogue entre le cerveau métabolique et la périphérieen_US
dc.description.sponsorshipRôle de Tbx3 dans la détermination de l'identité fonctionnelle des neurones POMC dans l'obésité - ANR-20-CE14-0046en_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enHypothalamus
dc.subject.enBlood–Brain Barrier
dc.title.enA plastic aggrecan barrier modulated by peripheral energy state gates metabolic signal access to arcuate neurons
dc.title.alternativeNat Communen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-024-50798-9en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed39112471en_US
bordeaux.journalNature Communicationsen_US
bordeaux.page6701en_US
bordeaux.volume15en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamRelations glie-neuroneen_US
bordeaux.teamPhysiopathologie de l'équilibre énergétique et obésitéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2024-08-07&rft.volume=15&rft.issue=1&rft.spage=6701&rft.epage=6701&rft.au=KUCZYNSKI-NOYAU,%20Laura&KARMANN,%20Sixtine&ALBERTON,%20Paolo&MARTINEZ-CORRAL,%20Ines&NAMPOOTHIRI,%20Sreekala&rft.genre=article


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