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The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex

dc.rights.licenseopenen_US
dc.contributor.authorMAKHANI, Naila
dc.contributor.authorLEBRUN-FRENAY, Christine
dc.contributor.authorSIVA, Aksel
dc.contributor.authorSHABANOVA, Veronika
dc.contributor.authorWASSMER, Evangeline
dc.contributor.authorSANTORO, Jonathan
dc.contributor.authorNARULA, Sona
dc.contributor.authorBRENTON, J. Nicholas
dc.contributor.authorMAR, Soe
dc.contributor.authorDURAND-DUBIEF, Francoise
dc.contributor.authorZEPHIR, Helene
dc.contributor.authorMATHEY, Guillaume
dc.contributor.authorROJAS, Juan
dc.contributor.authorDE SEZE, Jerome
dc.contributor.authorTENEMBAUM, Silvia
dc.contributor.authorSTONE, Robert Thompson
dc.contributor.authorCASEZ, Olivier
dc.contributor.authorCARRA-DALLIÈRE, Clarisse
dc.contributor.authorNEUTEBOOM, Rinze
dc.contributor.authorAHSAN, Nusrat
dc.contributor.authorARROYO, Hugo
dc.contributor.authorCABRE, Philippe
dc.contributor.authorGOMBOLAY, Grace
dc.contributor.authorINGLESE, Matilde
dc.contributor.authorLOUAPRE, Celine
dc.contributor.authorMARGONI, Monica
dc.contributor.authorPALAVRA, Filipe
dc.contributor.authorPOHL, Daniela
dc.contributor.authorREICH, Daniel
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorRUET, Aurélie
dc.contributor.authorTHOUVENOT, Eric
dc.contributor.authorTIMBY, Niklas
dc.contributor.authorTINTORE, Mar
dc.contributor.authorUYGUNOGLU, Ugur
dc.contributor.authorVARGAS, Wendy
dc.contributor.authorVENKATESWARAN, Sunita
dc.contributor.authorVERHELST, Helene
dc.contributor.authorWICKSTROM, Ronny
dc.contributor.authorAZEVEDO, Christina
dc.contributor.authorKANTARCI, Orhun
dc.contributor.authorSHAPIRO, Eugene
dc.contributor.authorOKUDA, Darin
dc.contributor.authorPELLETIER, Daniel
dc.date.accessioned2025-04-29T14:02:39Z
dc.date.available2025-04-29T14:02:39Z
dc.date.issued2024-07
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206488
dc.description.abstractEnBackground: Cerebrospinal fluid (CSF) and spinal MRIs are often obtained in children with the radiologically isolated syndrome (RIS) for diagnosis and prognosis. Factors affecting the frequency and timing of these tests are unknown. Objective: To determine whether age or sex were associated with (1) having CSF or spinal MRI obtained or (2) the timing of these tests. Methods: We analyzed children (≤ 18 y) with RIS enrolled in an international longitudinal study. Index scans met 2010/2017 multiple sclerosis (MS) MRI criteria for dissemination in space (DIS). We used Fisher’s exact test and multivariable logistic regression (covariates = age, sex, MRI date, MRI indication, 2005 MRI DIS criteria met, and race). Results: We included 103 children with RIS (67% girls, median age = 14.9 y). Children ≥ 12 y were more likely than children < 12 y to have CSF obtained (58% vs. 21%, adjusted odds ratio [AOR] = 4.9, p = 0.03). Pre-2017, girls were more likely than boys to have CSF obtained (n = 70, 79% vs. 52%, AOR = 4.6, p = 0.01), but not more recently (n = 30, 75% vs. 80%, AOR = 0.2, p = 0.1; p = 0.004 for interaction). Spinal MRIs were obtained sooner in children ≥ 12 y (median 11d vs. 159d, p = 0.03). Conclusions: Younger children with RIS may be at continued risk for misdiagnosis and misclassification of MS risk. Consensus guidelines are needed. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2024.
dc.language.isoENen_US
dc.subject.enMri
dc.subject.enChildren
dc.subject.enPediatric
dc.subject.enMultiple Sclerosis
dc.subject.enRadiologically Isolated Syndrome
dc.title.enThe diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex
dc.title.alternativeJ Neurolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00415-024-12289-1en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed38564056en_US
bordeaux.journalJournal of Neurologyen_US
bordeaux.page4019-4027en_US
bordeaux.volume271en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamRelations glie-neuroneen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDNational Multiple Sclerosis Societyen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20Neurology&amp;rft.date=2024-07&amp;rft.volume=271&amp;rft.issue=7&amp;rft.spage=4019-4027&amp;rft.epage=4019-4027&amp;rft.au=MAKHANI,%20Naila&amp;LEBRUN-FRENAY,%20Christine&amp;SIVA,%20Aksel&amp;SHABANOVA,%20Veronika&amp;WASSMER,%20Evangeline&amp;rft.genre=article


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