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Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same construct

dc.rights.licenseopenen_US
dc.contributor.authorDE GUGLIELMO, Giordano
dc.contributor.authorCARRETTE, Lieselot Lg
dc.contributor.authorKALLUPI, Marsida
dc.contributor.authorBRENNAN, Molly
dc.contributor.authorBOOMHOWER, Brent
dc.contributor.authorMATURIN, Lisa
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCONLISK, Dana
dc.contributor.authorSEDIGHIM, Sharona
dc.contributor.authorTIEU, Lani
dc.contributor.authorFANNON, Mckenzie
dc.contributor.authorMARTINEZ, Angelica
dc.contributor.authorVELARDE, Nathan
dc.contributor.authorOTHMAN, Dyar
dc.contributor.authorSICHEL, Ben
dc.contributor.authorRAMBORGER, Jarryd
dc.contributor.authorLAU, Justin
dc.contributor.authorKONONOFF, Jenni
dc.contributor.authorKIMBROUGH, Adam
dc.contributor.authorSIMPSON, Sierra
dc.contributor.authorSMITH, Lauren
dc.contributor.authorSHANKAR, Kokila
dc.contributor.authorBONNET-ZAHEDI, Sélène
dc.contributor.authorSNEDDON, Elizabeth
dc.contributor.authorAVELAR, Alicia
dc.contributor.authorPLASIL, Sonja
dc.contributor.authorMOSQUERA, Joseph
dc.contributor.authorCROOK, Caitlin
dc.contributor.authorCHUN, Lucas
dc.contributor.authorVANG, Ashley
dc.contributor.authorMILAN, Kristel
dc.contributor.authorSCHWEITZER, Paul
dc.contributor.authorLIN, Bonnie
dc.contributor.authorPENG, Beverly
dc.contributor.authorCHITRE, Apurva
dc.contributor.authorPOLLESKAYA, Oksana
dc.contributor.authorSOLBERG WOODS, Leah
dc.contributor.authorPALMER, Abraham
dc.contributor.authorGEORGE, Olivier
dc.date.accessioned2025-04-29T12:48:00Z
dc.date.available2025-04-29T12:48:00Z
dc.date.issued2024-11-01
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206484
dc.description.abstractEnAddiction is commonly characterized by escalation of drug intake, compulsive drug seeking, and continued use despite harmful consequences. However, the factors contributing to the transition from moderate drug use to these problematic patterns remain unclear, particularly regarding the role of sex. Many preclinical studies have been limited by small sample sizes, low genetic diversity, and restricted drug access, making it challenging to model significant levels of intoxication or dependence and translate findings to humans. To address these limitations, we characterized addiction-like behaviors in a large sample of >500 outbred heterogeneous stock (HS) rats using an extended cocaine self-administration paradigm (6 hr/daily). We analyzed individual differences in escalation of intake, progressive ratio (PR) responding, continued use despite adverse consequences (contingent foot shocks), and irritability-like behavior during withdrawal. Principal component analysis showed that escalation of intake, progressive ratio responding, and continued use despite adverse consequences loaded onto a single factor that was distinct from irritability-like behaviors. Categorizing rats into resilient, mild, moderate, and severe addiction-like phenotypes showed that females exhibited higher addiction-like behaviors, with a lower proportion of resilient individuals compared to males. These findings suggest that, in genetically diverse rats with extended drug access, escalation of intake, continued use despite adverse consequences, and PR responding are highly correlated measures of a shared underlying construct. Furthermore, our results highlight sex differences in resilience to addiction-like behaviors.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCocaine addiction
dc.subject.enCompulsive behavior
dc.subject.enEscalation
dc.subject.enHeterogeneous stock rats
dc.subject.enIndividual differences
dc.subject.enNeuroscience
dc.subject.enRat
dc.title.enLarge-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same construct
dc.title.alternativeElifeen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.7554/eLife.90422.2en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed39484794en_US
bordeaux.journalElifeen_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPsychobiologie de la vulnérabilité à l'addiction aux droguesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDNational Institute on Drug Abuseen_US
bordeaux.identifier.funderIDNational Institutes of Healthen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Elife&rft.date=2024-11-01&rft.au=DE%20GUGLIELMO,%20Giordano&CARRETTE,%20Lieselot%20Lg&KALLUPI,%20Marsida&BRENNAN,%20Molly&BOOMHOWER,%20Brent&rft.genre=article


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