Dye-Based Fluorescent Organic Nanoparticles, New Promising Tools for Optogenetics
| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | LESAS, Jérémy | |
| hal.structure.identifier | Centre hospitalier Charles Perrens [Bordeaux] | |
| dc.contributor.author | BIENVENU, Thomas C.M. | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| hal.structure.identifier | Institut des Sciences Moléculaires (Bordeaux) | |
| dc.contributor.author | KUREK, Eleonore | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | VERLHAC, Jean-Baptiste | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | GRIVET, Zoé | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | TÊTU, Maude | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | GIRARD, Delphine | |
| hal.structure.identifier | Interdisciplinary Institute for Neuroscience / Institut interdisciplinaire de neurosciences [Bordeaux] [IINS] | |
| dc.contributor.author | LANORE, Frédéric | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | BLANCHARD-DESCE, Mireille | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | HERRY, Cyril | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | DANIEL, Jonathan | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | DEJEAN, Cyril | |
| dc.date.accessioned | 2025-04-24T15:21:16Z | |
| dc.date.available | 2025-04-24T15:21:16Z | |
| dc.date.issued | 2025-01 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/206405 | |
| dc.description.abstractEn | Dye-based fluorescent organic nanoparticles are a specific class of nanoparticles obtained by nanoprecipitation in water of pure dyes only. While the photophysical and colloidal properties of the nanoparticles strongly depend on the nature of the aggregated dyes, their excellent brightness in the visible and in the near infrared make these nanoparticles a unique and versatile platform for in vivo application. This article examines the promising utilization of these nanoparticles for in vivo optogenetics applications. Their photophysical properties as well as their biocompatibility and their capacity to activate Chrimson opsin in vivo through the fluorescence reabsorption process are demonstrated. Additionally, an illustrative example of employing these nanoparticles in fear reduction in mice through closed-loop stimulation is presented. Through an optogenetic methodology, the nanoparticles demonstrate an ability to selectively manipulate neurons implicated in the fear response and diminish the latter. Dye-based fluorescent organic nanoparticles represent a promising and innovative strategy for optogenetic applications, holding substantial potential in the domain of translational neuroscience. This work paves the way for novel therapeutic modalities for neurological and neuropsychiatric disorders. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | Fluorescence | |
| dc.subject.en | Closed-Loop | |
| dc.subject.en | Neurostimulation | |
| dc.subject.en | Optogenetic | |
| dc.subject.en | Organic Nanoparticles | |
| dc.subject.en | Two-Photon Absorption | |
| dc.title.en | Dye-Based Fluorescent Organic Nanoparticles, New Promising Tools for Optogenetics | |
| dc.title.alternative | Adv Healthc Mater | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/adhm.202402132 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 39263839 | en_US |
| bordeaux.journal | Advanced Healthcare Materials | en_US |
| bordeaux.page | e2402132 | en_US |
| bordeaux.volume | 14 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.team | Circuits neuronaux des apprentissages associatifs | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | CC BY-NC-ND | en_US |
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