| dc.rights.license | open | en_US |
| hal.structure.identifier | Hôpital Haut-Lévêque [CHU Bordeaux] | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | GATTA-CHERIFI, Blandine | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | MOHAMMEDI, Kamel | |
| hal.structure.identifier | Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux] | |
| dc.contributor.author | CARIOU, Tanguy | |
| hal.structure.identifier | CHU Pitié-Salpêtrière [AP-HP] | |
| hal.structure.identifier | Nutrition et obésités: approches systémiques (UMR-S 1269) [Nutriomics] | |
| hal.structure.identifier | Centre de Référence du Syndrome de Prader-Willi [CHU Toulouse] [SPW-PRADORT] | |
| dc.contributor.author | POITOU, Christine | |
| hal.structure.identifier | CHU Pitié-Salpêtrière [AP-HP] | |
| dc.contributor.author | TOURAINE, Philippe | |
| hal.structure.identifier | Hospices Civils de Lyon [HCL] | |
| dc.contributor.author | RAVEROT, Gerald | |
| hal.structure.identifier | Marseille medical genetics - Centre de génétique médicale de Marseille [MMG] | |
| hal.structure.identifier | Institut Marseille Maladies Rares [MarMaRa] | |
| hal.structure.identifier | Service d'endocrinologie, diabète, maladies métaboliques [Hôpital de la Conception - APHM] | |
| dc.contributor.author | BRUE, Thierry | |
| hal.structure.identifier | Physiologie et physiopathologie endocriniennes [PHYSENDO] | |
| hal.structure.identifier | AP-HP. Université Paris Saclay | |
| hal.structure.identifier | Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] | |
| hal.structure.identifier | Université Paris-Saclay | |
| dc.contributor.author | CHANSON, Philippe | |
| hal.structure.identifier | MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale [MITOVASC] | |
| hal.structure.identifier | European Reference Network on rare endocrine conditions [Endo-ERN] | |
| hal.structure.identifier | Centre Hospitalier Universitaire d'Angers [CHU Angers] | |
| dc.contributor.author | ILLOUZ, Frédéric | |
| hal.structure.identifier | Service Endocrinologie, maladies métaboliques et nutrition [CHU Toulouse] | |
| dc.contributor.author | GRUNENWALD, Solange | |
| hal.structure.identifier | Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA] | |
| dc.contributor.author | CHABRE, Olivier | |
| hal.structure.identifier | Hôpital de la Cavale Blanche | |
| dc.contributor.author | SONNET, Emmanuel | |
| hal.structure.identifier | Marseille medical genetics - Centre de génétique médicale de Marseille [MMG] | |
| hal.structure.identifier | Institut Marseille Maladies Rares [MarMaRa] | |
| hal.structure.identifier | Laboratoire de Biochimie et de Biologie Moléculaire [Hôpital de la Conception - APHM] | |
| dc.contributor.author | CUNY, Thomas | |
| hal.structure.identifier | Institut Cochin [IC UM3 (UMR 8104 / U1016)] | |
| hal.structure.identifier | Hôpital Cochin [AP-HP] | |
| dc.contributor.author | BERTHERAT, Jerôme | |
| hal.structure.identifier | Hôpital Européen Georges Pompidou [APHP] [HEGP] | |
| dc.contributor.author | CZERNICHOW, Sébastien | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | FRISON, Eric | |
| hal.structure.identifier | Hôpital Haut-Lévêque [CHU Bordeaux] | |
| dc.contributor.author | TABARIN, Antoine | |
| dc.date.accessioned | 2025-04-24T07:01:52Z | |
| dc.date.available | 2025-04-24T07:01:52Z | |
| dc.date.issued | 2024-04-30 | |
| dc.identifier.issn | 0804-4643 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/206380 | |
| dc.description.abstractEn | Abstract Importance A major issue in the management of craniopharyngioma-related obesity (CRO) is the ineffectiveness of the current therapeutic approaches. Objective To study the efficacy of glucagon-like peptide-1 analogs compared with placebo in adults with obesity CRO. Design A double-blind multicenter superiority randomized clinical in trial in two parallel arms. Setting Eleven French University Hospital Centers. Participants Adults with CRO (body mass index > 30 kg/m²) without the sign of recurrence of craniopharyngioma in the past year. Interventions Exenatide or placebo injected subcutaneously twice a day during 26 weeks. Main Outcomes and Measures The primary outcome was the mean change in body weight at week 26 in the intention-to-treat population. Secondary outcomes were eating behavior, calories intake, energy expenditure, cardiovascular, metabolic risk factor, quality of life, and the tolerance profile. Results At week 26, weight decreased from baseline by a mean of −3.8 (SD 4.3) kg for exenatide and −1.6 (3.8) kg for placebo. The adjusted mean treatment difference was −3.1 kg (95% confidence interval [CI] −7.0 to 0.7, P = 0.11). Results were compatible with a higher reduction of hunger score with exenatide compared with placebo (estimated treatment difference in change from baseline to week 26: −2.3, 95% CI −4.5 to −0.2), while all other outcomes did not significantly differ between groups. Adverse events were more common with exenatide versus placebo, and occurred in, respectively, 19 (95%) participants (108 events) and 14 (70%) participants (54 events). Conclusions and Relevance Combined with intensive lifestyle interventions, a 26-week treatment with exenatide was not demonstrated superior to placebo to treat craniopharyngioma-related obesity. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | hypothalamic obesity | |
| dc.subject.en | craniopharyngioma | |
| dc.subject.en | glucagon-like peptide-1 analogs | |
| dc.subject.en | lifestyle intervention | |
| dc.title.en | Impact of exenatide on weight loss and eating behavior in adults with craniopharyngioma-related obesity: the CRANIOEXE randomized placebo-controlled trial | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/ejendo/lvae024 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Endocrinologie et métabolisme | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| dc.identifier.pubmed | 38450721 | en_US |
| bordeaux.journal | European Journal of Endocrinology | en_US |
| bordeaux.page | 257-265 | en_US |
| bordeaux.volume | 190 | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-04867934 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Journal%20of%20Endocrinology&rft.date=2024-04-30&rft.volume=190&rft.issue=4&rft.spage=257-265&rft.epage=257-265&rft.eissn=0804-4643&rft.issn=0804-4643&rft.au=GATTA-CHERIFI,%20Blandine&MOHAMMEDI,%20Kamel&CARIOU,%20Tanguy&POITOU,%20Christine&TOURAINE,%20Philippe&rft.genre=article | |
