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What are the determinants of functional decline in older adults with cancer? Results from the INCAPAC study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSIMON, Yvanna
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELVA, Fleur
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBALDI, Isabelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOUREAU, Gaelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEGUYADER-PEYROU, Sandra
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAMIEVA, Helene
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMATHOULIN PELISSIER, Simone
IDREF: 071358587
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPERES, Karine
ORCID: 0000-0002-0720-0684
IDREF: 080634001
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGALVIN, Angeline
dc.date.accessioned2025-04-18T11:38:22Z
dc.date.available2025-04-18T11:38:22Z
dc.date.issued2025-03-22
dc.identifier.issn1879-4076en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206303
dc.description.abstractEnINTRODUCTION: Older adults with cancer are exposed to greater difficulties in carrying out their daily activities due to cancer itself, its treatment, or both. The aim of this study was to describe functional decline after cancer diagnosis and to investigate the determinants of this decline among older individuals with cancer. MATERIALS AND METHODS: Using the Gironde cancer registries, older subjects (≥65 years) with a diagnosis of cancer between 2005 and 2018 were identified in three prospective cohorts on aging. Functional decline was defined as an increase of 1 point for Activities of Daily Living (ADL), 2 points for Instrumental Activities of Daily Living (IADL), and 3 points for the overall score (ADL + IADL) between cancer pre- and post-diagnosis visits. Logistic regression models were used to identify determinants of functional decline among older subjects who underwent a post-diagnostic assessment. Additionally, multinomial logistic regression models were performed to account for individuals who had died prior to the post-diagnostic cancer visit. RESULTS: A total of 306 individuals followed-up after the cancer diagnosis were included (median age at cancer diagnosis: 83; 44 % female). Older age at cancer, low educational level, impaired initial functional status, and poor five-year cancer-related prognosis were significantly associated with functional decline across all three scores. Multinomial logistic regression analyses (n = 489) yielded similar results, but only cancer-related factors, specifically unfavorable vital prognosis, were associated with higher risk of death. DISCUSSION: Functional decline in older individuals with cancer is both multifactorial and multidimensional. Further studies are needed to disentangle the effects of cancer and aging.
dc.language.isoENen_US
dc.subject.enCancer
dc.subject.enCancer registries
dc.subject.enCohort studies
dc.subject.enFunctional status
dc.subject.enOlder people
dc.title.enWhat are the determinants of functional decline in older adults with cancer? Results from the INCAPAC study
dc.title.alternativeJ Geriatr Oncolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jgo.2025.102223en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40121858en_US
bordeaux.journalJournal of Geriatric Oncologyen_US
bordeaux.page102223en_US
bordeaux.volume16en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamACTIVE_BPHen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-05039583
hal.version1
hal.date.transferred2025-04-18T11:38:25Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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