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Histo-blood group ABO system transferase plasma levels and risk of future venous thromboembolism: The HUNT Study

dc.rights.licenseopenen_US
dc.contributor.authorONSAKER, Asbjorn Lund
dc.contributor.authorARNTZEN, Anna Yang
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTREGOUET, David-Alexandre
dc.contributor.authorNOST, Therese Haugdahl
dc.contributor.authorTANG, Weihong
dc.contributor.authorGUAN, Weihua
dc.contributor.authorJONASSON, Christian
dc.contributor.authorMORANGE, Pierre-Emmanuel
dc.contributor.authorHINDBERG, Kristian Dalsbo
dc.contributor.authorFOLSOM, Aaron R
dc.contributor.authorHVEEM, Kristian
dc.contributor.authorMORELLI, Vania M
dc.contributor.authorHANSEN, John-Bjarne
dc.date.accessioned2025-04-14T12:34:24Z
dc.date.available2025-04-14T12:34:24Z
dc.date.issued2025-02-26
dc.identifier.issn1528-0020en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206188
dc.description.abstractEnThe non-O blood group is a well-established risk factor for venous thromboembolism (VTE). However, the association between plasma levels of the histo-blood group ABO system transferase (BGAT), the gene product of the ABO locus, and VTE risk remains unclear. We aimed to investigate the association between plasma BGAT levels and risk of future VTE, and whether this relationship was mediated by plasma von Willebrand factor (VWF) or coagulation factor VIII (FVIII) as VWF is glycosylated by BGAT. Incident VTE-cases (n=294) and randomly sampled age- and-sex-weighted subcohort (n=1,066) were derived from the third survey of the Trøndelag Health Study (HUNT3). Baseline plasma samples (2006-08) were subjected to the SomaScan® aptamer-based-7K platform for protein measurements. Weighted Cox regression was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) across BGAT quartiles. We found that ABO haplotypes (A1/A2/B/O1/O2) explained ~80% of the BGAT plasma variability. Participants with BGAT levels in the highest quartile had 2-fold higher VTE risk (HR 2.12, 95%CI:1.39-3.22) compared with those with BGAT in the lowest quartile in age-, sex- and sample batch-adjusted models. The associations were particularly pronounced for unprovoked VTE (HR 3.71, 95%CI:1.79-7.67) and deep vein thrombosis (HR 3.28, 95%CI:1.63-6.59). The HRs were similar after further adjustment for body mass index, C-reactive protein, and estimated estimated glomerular filtration rate, and moderately attenuated when adding VWF or FVIII plasma levels to the models. Our findings indicate that elevated BGAT plasma levels are associated with increased risk of future VTE beyond what is explained by VWF and FVIII.
dc.language.isoENen_US
dc.title.enHisto-blood group ABO system transferase plasma levels and risk of future venous thromboembolism: The HUNT Study
dc.title.alternativeBlooden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1182/blood.2024025923en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40009491en_US
bordeaux.journalBlooden_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-05033317
hal.version1
hal.date.transferred2025-04-14T12:34:27Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Blood&rft.date=2025-02-26&rft.eissn=1528-0020&rft.issn=1528-0020&rft.au=ONSAKER,%20Asbjorn%20Lund&ARNTZEN,%20Anna%20Yang&TREGOUET,%20David-Alexandre&NOST,%20Therese%20Haugdahl&TANG,%20Weihong&rft.genre=article


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