Outcomes and challenges in adolescents living with HIV in France: A nationwide cohort study over 35 years (1985-2020)
| dc.rights.license | open | en_US |
| dc.contributor.author | DOLLFUS, Catherine | |
| dc.contributor.author | CHENADEC, Jerome LE | |
| dc.contributor.author | RELIQUET, Veronique | |
| dc.contributor.author | ALBY-LAURENT, Fanny | |
| dc.contributor.author | BREHIN, Camille | |
| dc.contributor.author | CASERIS, Marion | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | RUNEL-BELLIARD, Camille | |
| dc.contributor.author | BLANCHE, Stephane | |
| dc.contributor.author | WARSZAWSKI, Josiane | |
| dc.contributor.author | FAYE, Albert | |
| dc.contributor.author | FRANGE, Pierre | |
| dc.contributor.author | FRENCH, Anrs- M. I. E. C. O. Study Group | |
| dc.date.accessioned | 2025-04-14T08:27:23Z | |
| dc.date.available | 2025-04-14T08:27:23Z | |
| dc.date.issued | 2025-05-01 | |
| dc.identifier.issn | 1473-5571 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/206154 | |
| dc.description.abstractEn | Objective: Most data published on adolescents living with HIV (ALH) have been collected before the large diffusion of second-generation integrase strand transfer inhibitors (INSTI) among the pediatric population. We analyzed the nationwide ANRS-MIE CO10 Pediatric cohort to assess the changes over time in health and social outcomes of French ALH. Design: The cohort enrolled children born in France since 1985 and, from 2005, children diagnosed with HIV at ≤13 years, including those born abroad if antiretroviral-naive at first medical care in France. Methods: Adolescents aged ≥10 years at their last visit were included in this analysis. Their characteristics were compared between three periods of birth (1985-1993, 1994-1999, 2000-2010). Results: Overall, 529 ALH were included. Their median age at first HAART initiation decreased from 94 to 29 months (p < 0·0001). At the last evaluation, the proportions of ALH receiving HAART, receiving INSTI, having HIV-RNA < 50 copies/mL and having CD4 count ≥500/μL increased over time (p < 0.0001), reaching 98·7%, 53·3%, 81·3% and 85·0%, respectively, for those born in 2000-2010. The proportion of maternal and paternal orphans decreased until 14·4% and 11·0%, respectively, for ALH born recently. Compared to middle adolescents (15-17 years) born in 1994-1999, those born in 2000-2010 demonstrated higher academic success (69·2% versus 42·3%) and less frequent academic failure (4·6% versus 6·2%). Conclusions: Despite spectacular improvement in their health and immunovirological status, ALH remain vulnerable compared to other French adolescents, with a higher risk of being orphan and/or experiencing academic failure. Specific interventions are required to improve their global quality of life. Copyright © 2025 Wolters Kluwer Health, Inc. | |
| dc.language.iso | EN | en_US |
| dc.title.en | Outcomes and challenges in adolescents living with HIV in France: A nationwide cohort study over 35 years (1985-2020) | |
| dc.title.alternative | AIDS | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1097/QAD.0000000000004121 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 39813288 | en_US |
| bordeaux.journal | AIDS. Official journal of the international AIDS Society | en_US |
| bordeaux.page | 667-675 | en_US |
| bordeaux.volume | 39 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 6 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Coll_PHARES_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=AIDS.%20Official%20journal%20of%20the%20international%20AIDS%20Society&rft.date=2025-05-01&rft.volume=39&rft.issue=6&rft.spage=667-675&rft.epage=667-675&rft.eissn=1473-5571&rft.issn=1473-5571&rft.au=DOLLFUS,%20Catherine&CHENADEC,%20Jerome%20LE&RELIQUET,%20Veronique&ALBY-LAURENT,%20Fanny&BREHIN,%20Camille&rft.genre=article |
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