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Polycationic phosphorous dendrimer potentiates multiple antibiotics against drug-resistant mycobacterial pathogens

dc.rights.licenseopenen_US
dc.contributor.authorIMRAN, Mohmmad
dc.contributor.authorSINGH, Shriya
dc.contributor.authorAHMAD, Mohammad Naiyaz
dc.contributor.authorMALIK, Pradip
dc.contributor.authorMUKHOPADHYAY, Atri
dc.contributor.authorYADAV, Karan Singh
dc.contributor.authorGUPTA, Umesh D
dc.contributor.authorMUGALE, Madhav N
dc.contributor.authorMITRA, Kalyan
dc.contributor.authorSRIVASTAVA, Kishore K
dc.contributor.authorCHOPRA, Sidharth
dc.contributor.authorMIGNANI, Serge
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorAPARTSIN, Evgeny
dc.contributor.authorMAJORAL, Jean-Pierre
dc.contributor.authorDASGUPTA, Arunava
dc.date.accessioned2025-04-04T08:19:16Z
dc.date.available2025-04-04T08:19:16Z
dc.date.issued2024-04-01
dc.identifier.issn0753-3322en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205951
dc.description.abstractEnMycobacterium tuberculosis (Mtb), causative agent of tuberculosis (TB) and non-tubercular mycobacterial (NTM) pathogens such as Mycobacterium abscessus are one of the most critical concerns worldwide due to increased drug-resistance resulting in increased morbidity and mortality. Therefore, focusing on developing novel therapeutics to minimize the treatment period and reducing the burden of drug-resistant Mtb and NTM infections are an urgent and pressing need. In our previous study, we identified anti-mycobacterial activity of orally bioavailable, non-cytotoxic, polycationic phosphorus dendrimer 2G0 against Mtb. In this study, we report ability of 2G0 to potentiate activity of multiple classes of antibiotics against drug-resistant mycobacterial strains. The observed synergy was confirmed using time-kill kinetics and revealed significantly potent activity of the combinations as compared to individual drugs alone. More importantly, no re-growth was observed in any tested combination. The identified combinations were further confirmed in intra-cellular killing assay as well as murine model of NTM infection, where 2G0 potentiated the activity of all tested antibiotics significantly better than individual drugs. Taken together, this nanoparticle with intrinsic antimycobacterial properties has the potential to represents an alternate drug candidate and/or a novel delivery agent for antibiotics of choice for enhancing the treatment of drug-resistant mycobacterial pathogens.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enAMR
dc.subject.enIn vivo activity
dc.subject.enNon-tuberculous mycobacteria
dc.subject.enPolycationic-phosphorous dendrimers
dc.subject.enSynergy
dc.title.enPolycationic phosphorous dendrimer potentiates multiple antibiotics against drug-resistant mycobacterial pathogens
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.biopha.2024.116289en_US
dc.subject.halChimie/Matériauxen_US
dc.identifier.pubmed38452653en_US
bordeaux.journalBiomedicine and Pharmacotherapyen_US
bordeaux.page116289en_US
bordeaux.volume173en_US
bordeaux.hal.laboratoriesCBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomedicine%20and%20Pharmacotherapy&rft.date=2024-04-01&rft.volume=173&rft.spage=116289&rft.epage=116289&rft.eissn=0753-3322&rft.issn=0753-3322&rft.au=IMRAN,%20Mohmmad&SINGH,%20Shriya&AHMAD,%20Mohammad%20Naiyaz&MALIK,%20Pradip&MUKHOPADHYAY,%20Atri&rft.genre=article


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