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Urea Level and Depression in Patients with Chronic Kidney Disease

dc.rights.licenseopenen_US
dc.contributor.authorLEVASSORT, Hélène
dc.contributor.authorBOUCQUEMONT, Julie
dc.contributor.authorLAMBERT, Oriane
dc.contributor.authorLIABEUF, Sophie
dc.contributor.authorLAVILLE, Solene M.
dc.contributor.authorTEILLET, Laurent
dc.contributor.authorTABCHEH, Abdel-Hay
dc.contributor.authorFRIMAT, Luc
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCOMBE, Christian
dc.contributor.authorFOUQUE, Denis
dc.contributor.authorLAVILLE, Maurice
dc.contributor.authorJACQUELINET, Christian
dc.contributor.authorHELMER, Catherine
dc.contributor.authorALENCAR DE PINHO, Natalia
dc.contributor.authorPÉPIN, Marion
dc.contributor.authorMASSY, Ziad A.
dc.date.accessioned2025-03-24T15:08:26Z
dc.date.available2025-03-24T15:08:26Z
dc.date.issued2024
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205653
dc.description.abstractEnDepression is common in patients with chronic kidney disease (CKD). Experimental studies suggest the role of urea toxicity in depression. We assessed both the incidence of antidepressant prescriptions and depressive symptoms (measured by CESD (Center for Epidemiologic Depression) scale) in 2505 patients with CKD (Stage 3–4) followed up over 5 years in the Chronic Kidney Disease Renal Epidemiology and Information Network (CKD-REIN) cohort. We used a joint model to assess the association between the serum urea level and incident antidepressant prescriptions, and mixed models for the association between the baseline serum urea level and CESD score over the 5-year follow-up. Among the 2505 patients, 2331 were not taking antidepressants at baseline. Of the latter, 87 started taking one during a median follow-up of 4.6 years. After adjustment for confounding factors, the hazard ratio for incident antidepressant prescription associated with the serum urea level (1.28 [95%CI, 0.94,1.73] per 5 mmol/L increment) was not significant. After adjustment, the serum urea level was associated with the mean change in the CESD score (β = 0.26, [95%CI, 0.11,0.41] per 5 mmol/L increment). Depressive symptoms burden was associated with serum urea level unlike depression events. Further studies are needed to draw firm conclusions and better understand the mechanisms of depression in CKD. © 2024 by the authors.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectChronic kidney disease
dc.subjectDepression
dc.subjectkidney brain axis
dc.subjectUrea
dc.title.enUrea Level and Depression in Patients with Chronic Kidney Disease
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/toxins16070326en_US
dc.subject.halSciences du Vivant [q-bio]en_US
bordeaux.journalToxinsen_US
bordeaux.volume16en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Toxins&rft.date=2024&rft.volume=16&rft.issue=7&rft.au=LEVASSORT,%20H%C3%A9l%C3%A8ne&BOUCQUEMONT,%20Julie&LAMBERT,%20Oriane&LIABEUF,%20Sophie&LAVILLE,%20Solene%20M.&rft.genre=article


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