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Haemoglobin trajectories in chronic kidney disease and risk of major adverse cardiovascular events

dc.rights.licenseopenen_US
hal.structure.identifierCIC Bordeaux
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLE GALL, Lisa
IDREF: 222223472
hal.structure.identifierCIC Bordeaux
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jérôme
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierService de Néphrologie-transplantation-dialyse [Bordeaux]
dc.contributor.authorCOMBE, Christian
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPHILIPPS, Viviane
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST-LIMA, Cécile
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUSSARTRE, Maris
dc.contributor.authorDRÜEKE, Tilman
dc.contributor.authorCHOUKROUN, Gabriel
dc.contributor.authorFOUQUE, Denis
dc.contributor.authorFRIMAT, Luc
dc.contributor.authorJACQUELINET, Christian
dc.contributor.authorLAVILLE, Maurice
dc.contributor.authorLIABEUF, Sophie
dc.contributor.authorPECOITS-FILHO, Roberto
dc.contributor.authorMASSY, Ziad A.
dc.contributor.authorSTENGEL, Bénédicte
dc.contributor.authorPINHO, Natalia Alencar De
hal.structure.identifierCIC Bordeaux
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFFONDRÉ, Karen
hal.structure.identifierCIC Bordeaux
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPREZELIN-REYDIT, Mathilde
dc.date.accessioned2025-03-24T14:50:11Z
dc.date.available2025-03-24T14:50:11Z
dc.date.issued2024-03-27
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205652
dc.description.abstractEnBackground. The trajectories of haemoglobin in patients with chronic kidney disease (CKD) have been poorly described. In such patients, we aimed to identify typical haemoglobin trajectory profiles and estimate their risks of major adverse cardiovascular events (MACE). Methods. We used 5-year longitudinal data from the CKD-REIN cohort patients with moderate to severe CKD enrolled from 40 nationally representative nephrology clinics in France. A joint latent class model was used to estimate, in different classes of haemoglobin trajectory, the competing risks of (i) MACE + defined as the first event among cardiovascular death, non-fatal myocardial infarction, stroke or hospitalization for acute heart failure, (ii) initiation of kidney replacement therapy (KRT) and (iii) non-cardiovascular death. Results. During the follow-up, we gathered 33 874 haemoglobin measurements from 3011 subjects (median, 10 per patient). We identified five distinct haemoglobin trajectory profiles. The predominant profile (n = 1885, 62.6%) showed an overall stable trajectory and low risks of events. The four other profiles had nonlinear declining trajectories: early strong decline (n = 257, 8.5%), late strong decline (n = 75, 2.5%), early moderate decline (n = 356, 11.8%) and late moderate decline (n = 438, 14.6%). The four profiles had different risks of MACE, while the risks of KRT and non-cardiovascular death consistently increased from the haemoglobin decline. Conclusion. In this study, we observed that two-thirds of patients had a stable haemoglobin trajectory and low risks of adverse events. The other third had a nonlinear trajectory declining at different rates, with increased risks of events. Better attention should be paid to dynamic changes of haemoglobin in CKD. © The Author(s) 2023.
dc.language.isoENen_US
dc.subjectnaemia
dc.subjecthaemoglobin
dc.subjectjoint latent linear mixed model
dc.subjectmajor adverse cardiovascular events
dc.subjecttrajectories
dc.title.enHaemoglobin trajectories in chronic kidney disease and risk of major adverse cardiovascular events
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ndt/gfad235en_US
dc.subject.halSciences du Vivant [q-bio]en_US
bordeaux.journalNephrology Dialysis Transplantationen_US
bordeaux.page669 – 682en_US
bordeaux.volume39en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nephrology%20Dialysis%20Transplantation&rft.date=2024-03-27&rft.volume=39&rft.issue=4&rft.spage=669%20%E2%80%93%20682&rft.epage=669%20%E2%80%93%20682&rft.au=LE%20GALL,%20Lisa&HARAMBAT,%20J%C3%A9r%C3%B4me&COMBE,%20Christian&PHILIPPS,%20Viviane&PROUST-LIMA,%20C%C3%A9cile&rft.genre=article


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