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Refining criteria for a neurodevelopmental sub-phenotype of bipolar disorders: a FondaMental Advanced Centers of Expertise for Bipolar Disorders study

dc.rights.licenseopenen_US
dc.contributor.authorLEFRERE, Antoine
dc.contributor.authorGODIN, Ophélia
dc.contributor.authorJAMAIN, Stéphane
dc.contributor.authorDANSOU, Yecodji
dc.contributor.authorSAMALIN, Ludovic
dc.contributor.authorALDA, Martin
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
dc.contributor.authorAUBIN, Valérie
dc.contributor.authorREY, Romain
dc.contributor.authorCONTU, Martina
dc.contributor.authorCOURTET, Philippe
dc.contributor.authorDUBERTRET, Caroline
dc.contributor.authorHAFFEN, Emmanuel
dc.contributor.authorJANUEL, Dominique
dc.contributor.authorLEBOYER, Marion
dc.contributor.authorLLORCA, Pierre Michel
dc.contributor.authorMARLINGE, Emeline
dc.contributor.authorMANCHIA, Mirko
dc.contributor.authorNEILSON, Samantha
dc.contributor.authorOLIÉ, Emilie
dc.contributor.authorPARIBELLO, Pasquale
dc.contributor.authorPINNA, Marco
dc.contributor.authorPOLOSAN, Mircea
dc.contributor.authorROUX, Paul
dc.contributor.authorSCHWAN, Raymund
dc.contributor.authorTONDO, Leonardo
dc.contributor.authorWALTER, Michel
dc.contributor.authorTZAVARA, Eleni
dc.contributor.authorAUZIAS, Guillaume
dc.contributor.authorDERUELLE, Christine
dc.contributor.authorETAIN, Bruno
dc.contributor.authorBELZEAUX, Raoul
dc.date.accessioned2025-03-24T10:41:12Z
dc.date.available2025-03-24T10:41:12Z
dc.date.issued2024-10
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205646
dc.description.abstractEnBackground: Bipolar disorder (BD) is a complex and heterogeneous psychiatric disorder. It has been suggested that neurodevelopmental factors contribute to the etiology of BD, but a specific neurodevelopmental phenotype (NDP) of the disorder has not been identified. Our objective was to define and characterize an NDP in BD and validate its associations with clinical outcomes, polygenic risk scores, and treatment responses. Methods: We analyzed the FondaMental Advanced Centers of Expertise for Bipolar Disorders cohort of 4468 patients with BD, a validation cohort of 101 patients with BD, and 2 independent replication datasets of 274 and 89 patients with BD. Using factor analyses, we identified a set of criteria for defining NDP. Next, we developed a scoring system for NDP load and assessed its association with prognosis, neurological soft signs, polygenic risk scores for neurodevelopmental disorders, and responses to treatment using multiple regressions, adjusted for age and gender with bootstrap replications. Results: Our study established an NDP in BD consisting of 9 clinical features: advanced paternal age, advanced maternal age, childhood maltreatment, attention-deficit/hyperactivity disorder, early onset of BD, early onset of substance use disorders, early onset of anxiety disorders, early onset of eating disorders, and specific learning disorders. Patients with higher NDP load showed a worse prognosis and increased neurological soft signs. Notably, these individuals exhibited a poorer response to lithium treatment. Furthermore, a significant positive correlation was observed between NDP load and polygenic risk score for attention-deficit/hyperactivity disorder, suggesting potential overlapping genetic factors or pathophysiological mechanisms between BD and attention-deficit/hyperactivity disorder. Conclusions: The proposed NDP constitutes a promising clinical tool for patient stratification in BD.
dc.language.isoENen_US
dc.subject.enBipolar Disorder
dc.subject.enGenomics
dc.subject.enLithium Response
dc.subject.enNeurodevelopment
dc.subject.enNeurological Soft Sign
dc.subject.enStratification
dc.title.enRefining criteria for a neurodevelopmental sub-phenotype of bipolar disorders: a FondaMental Advanced Centers of Expertise for Bipolar Disorders study
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.biopsych.2024.09.025en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed39395474en_US
bordeaux.journalBiological Psychiatryen_US
bordeaux.pageS0006-3223(24)01654-8en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biological%20Psychiatry&rft.date=2024-10&rft.spage=S0006-3223(24)01654-8&rft.epage=S0006-3223(24)01654-8&rft.au=LEFRERE,%20Antoine&GODIN,%20Oph%C3%A9lia&JAMAIN,%20St%C3%A9phane&DANSOU,%20Yecodji&SAMALIN,%20Ludovic&rft.genre=article


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