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Cellularized Biomaterials Used as Gingival Connective Tissue Substitutes In Vivo: A Systematic Review

dc.rights.licenseopenen_US
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorDÉCHELETTE, Camille
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorSMIRANI, Rawen
IDREF: 20360718X
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorMÉDINA, Chantal
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorNAVEAU, Adrien
dc.date.accessioned2025-03-21T13:47:59Z
dc.date.available2025-03-21T13:47:59Z
dc.date.issued2024-06-27
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205631
dc.description.abstractEnDeveloping an in vitro model of gingival connective tissue that mimics the original structure and composition of gingiva for clinical grafting is relevant for personalized treatment of missing gingiva. Using tissue engineering techniques allows bypassing limitations encountered with existing solutions to increase oral soft tissue volume. This review aims to systematically analyze the different currently existing cellularized materials and technologies used to engineer gingival substitutes for in vivo applications. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. An electronic search on PubMed, Scopus, Web of Science, and Cochrane Library databases was conducted to identify suitable studies. In vivo studies about gingival substitutes and grafts containing oral cells compared with a control to investigate the graft remodeling were included. Risk of bias in the included studies was assessed using the Systematic Review Center for Laboratory animal Experimentation (SYRCLE) 10-item checklist. Out of 631 screened studies, 19 were included. Animal models were mostly rodents, and the most used implantation was subcutaneous. According to the SYRCLE tool, low-to-unclear risk of bias was prevalent. Studies checked vascularization and extracellular remodeling up to 60 days after implantation of the cellularized biomaterial. Cells used were mostly fibroblasts and stem cells from oral origin. Grafts presenting vascularization potential after implantation were produced by tissue engineering technologies including cell seeding or embedding for 14, cell sheets for 2, microsphere for 1, and extrusion 3D bioprinting for 2. Components used to build the scaffold containing the cells are all naturally derived and are mainly fibrin, gelatin, collagen, agarose, alginate, fibroin, guar gum, hyaluronic acid, and decellularized extracellular matrix. The most recurring crosslinking method was using chemicals. All studies except one reported vascularization of the graft after implantation, and some detailed extracellular matrix remodeling. Current solutions are not efficient enough. By assessing the relevant studies on the subject, this systematic review showed that a diversity of cellularized biomaterials substituting gingival connective tissue enables vascularization and extracellular remodeling. Taking the results of this review into account could help improve current bio-inks used in 3D bioprinting for in vivo applications compensating for gingival loss. Copyright 2024, Mary Ann Liebert, Inc., publishers.
dc.language.isoENen_US
dc.subject.engingiva regeneration; oral tissue; remodeling; systematic review; tissue engineering; vascularization
dc.title.enCellularized Biomaterials Used as Gingival Connective Tissue Substitutes In Vivo: A Systematic Review
dc.typeArticle de revueen_US
dc.identifier.doi10.1089/ten.teb.2024.0031en_US
dc.subject.halSciences du Vivant [q-bio]en_US
bordeaux.journalTissue Engineering - Part Ben_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-05000882
hal.version1
hal.date.transferred2025-03-21T13:48:01Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Tissue%20Engineering%20-%20Part%20B&rft.date=2024-06-27&rft.au=D%C3%89CHELETTE,%20Camille&SMIRANI,%20Rawen&M%C3%89DINA,%20Chantal&NAVEAU,%20Adrien&rft.genre=article


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