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Hemodynamic evaluation of biomaterial-based surgery for Tetralogy of Fallot using a biorobotic heart, in silico, and ovine models

dc.rights.licenseopenen_US
dc.contributor.authorSINGH, Manisha
dc.contributor.authorROUBERTIE, François
dc.contributor.authorOZTURK, Caglar
dc.contributor.authorBORCHIELLINI, Paul
dc.contributor.authorRAMES, Adeline
dc.contributor.authorBONNEMAIN, Jean
dc.contributor.authorGOLLOB, Samuel Dutra
dc.contributor.authorWANG, Sophie X.
dc.contributor.authorNAULIN, Jérôme
dc.contributor.authorEL HAMRANI, Dounia
dc.contributor.authorDUGOT-SENANT, Nathalie
dc.contributor.authorGOSSELIN, Isalyne
dc.contributor.authorGRENET, Célia
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorL’HEUREUX, Nicolas
dc.contributor.authorROCHE, Ellen T.
dc.contributor.authorKAWECKI, Fabien
dc.date.accessioned2025-03-21T13:42:00Z
dc.date.available2025-03-21T13:42:00Z
dc.date.issued2024-07-10
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205630
dc.description.abstractEnTetralogy of Fallot is a congenital heart disease affecting newborns and involves stenosis of the right ventricular outflow tract (RVOT). Surgical correction often widens the RVOT with a transannular enlargement patch, but this causes issues including pulmonary valve insufficiency and progressive right ventricle failure. A monocusp valve can prevent pulmonary regurgitation; however, valve failure resulting from factors including leaflet design, morphology, and immune response can occur, ultimately resulting in pulmonary insufficiency. A multimodal platform to quantitatively evaluate the effect of shape, size, and material on clinical outcomes could optimize monocusp design. This study introduces a benchtop soft biorobotic heart model, a computational fluid model of the RVOT, and a monocusp valve made from an entirely biological cell-assembled extracellular matrix (CAM) to tackle the multifaceted issue of monocusp failure. The hydrodynamic and mechanical performance of RVOT repair strategies was assessed in biorobotic and computational platforms. The monocusp valve design was validated in vivo in ovine models through echocardiography, cardiac magnetic resonance, and catheterization. These models supported assessment of surgical feasibility, handling, suturability, and hemodynamic and mechanical monocusp capabilities. The CAM-based monocusp offered a competent pulmonary valve with regurgitation of 4.6 ± 0.9% and a transvalvular pressure gradient of 4.3 ± 1.4 millimeters of mercury after 7 days of implantation in sheep. The biorobotic heart model, in silico analysis, and in vivo RVOT modeling allowed iteration in monocusp design not now feasible in a clinical environment and will support future surgical testing of biomaterials for complex congenital heart malformations. Copyright © 2024 Th Authors, some rights reserved
dc.language.isoENen_US
dc.title.enHemodynamic evaluation of biomaterial-based surgery for Tetralogy of Fallot using a biorobotic heart, in silico, and ovine models
dc.typeArticle de revueen_US
dc.identifier.doi10.1126/scitranslmed.adk2936en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.subject.halInformatique [cs]/Biotechnologieen_US
bordeaux.journalScience Translational Medicineen_US
bordeaux.volume16en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.issue755en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Science%20Translational%20Medicine&rft.date=2024-07-10&rft.volume=16&rft.issue=755&rft.au=SINGH,%20Manisha&ROUBERTIE,%20Fran%C3%A7ois&OZTURK,%20Caglar&BORCHIELLINI,%20Paul&RAMES,%20Adeline&rft.genre=article


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