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dc.rights.licenseopenen_US
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorROUDIER, Gaëtan
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorHOURQUES, Marie
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorDA SILVA, Nicolas
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorGLUAIS, Maude
hal.structure.identifierInstitut de Mécanique et d'Ingénierie de Bordeaux [I2M]
dc.contributor.authorBINYET, Emmanuel
hal.structure.identifierInstitut de Mécanique et d'Ingénierie de Bordeaux [I2M]
dc.contributor.authorOLIVE, Jean-Marc
IDREF: 06039563X
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorL’HEUREUX, Nicolas
dc.date.accessioned2025-03-20T16:39:18Z
dc.date.available2025-03-20T16:39:18Z
dc.date.issued2023-11-24
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205592
dc.description.abstractEnTissue-engineered vascular grafts (TEVGs) made of human textiles have been recently introduced and offer remarkable biocompatibility as well as tunable mechanical properties. The approach combines the use of cell-assembled extracellular matrix (CAM) threads, produced by cultured cells in vitro, with weaving, a versatile assembly method that gives fine control over graft properties. Herein, we investigated how production parameters can modify the geometrical and mechanical properties of TEVGs to better match that of native blood vessels in order to provide long-term patency. Our goals were to decrease the mechanical strength and the luminal surface profile of our first generation of woven TEVGs, while maintaining low transmural permeability and good suture retention strength. Different TEVGs were produced by varying CAM sheet strength as well as weaving parameters such as warp count, weft ribbons width, and weft tension. An optimized design reduced the burst pressure by 35%, wall thickness by 38% and increased compliance by 269%. The improved TEVG had properties closer to that of native blood vessels, with a burst pressure of 3492 mmHg, a wall thickness of 0.69 mm, and a compliance of 4.8%/100 mmHg, while keeping excellent suture retention strength (4.7 N) and low transmural permeability (24 ml·min−1·cm−2). Moreover, the new design reduced the luminal surface profile by 48% and utilized 47% less CAM. With a comparable design, the use of decellularized CAM threads, instead of devitalized ones, led to TEVGs with much more permeable walls and higher burst pressure. The next step is to implant this optimized graft in an allogeneic sheep model of arteriovenous shunt to assess its in vivo remodeling and performance. © 2023 The Author(s). Published by IOP Publishing Ltd.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enBiological textiles
dc.subject.enExtracellular matrix
dc.subject.enMechanical properties
dc.subject.enTissue engineering
dc.subject.enVascular graft
dc.subject.enWeaving parameters
dc.title.enEffects of weaving parameters on the properties of completely biological tissue-engineered vascular grafts
dc.typeArticle de revueen_US
dc.identifier.doi10.1088/1758-5090/ad0d14en_US
dc.subject.halSciences du Vivant [q-bio]en_US
bordeaux.journalBiofabricationen_US
bordeaux.volume16en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.hal.laboratoriesInstitut de Mécanique et d'Ingénierie [I2M]en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biofabrication&rft.date=2023-11-24&rft.volume=16&rft.issue=1&rft.au=ROUDIER,%20Ga%C3%ABtan&HOURQUES,%20Marie&DA%20SILVA,%20Nicolas&GLUAIS,%20Maude&BINYET,%20Emmanuel&rft.genre=article


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