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Obesogenic diet induces sex-specific alterations of contextual fear memory and associated hippocampal activity in mice

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorN'DIAYE, Matéo
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDUCOURNEAU, Eva-Gunnel
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBAKOYIANNIS, Ioannis
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorPOTIER, Mylène
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAFENETRE, Pauline
IDREF: 230337236
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA, Guillaume
dc.date.accessioned2025-03-20T10:49:13Z
dc.date.available2025-03-20T10:49:13Z
dc.date.issued2024-06
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205581
dc.description.abstractEnIn addition to metabolic and cardiovascular disorders, obesity is associated with cognitive deficits in humans and animal models. We have previously shown that obesogenic high-fat and sugar diet intake during adolescence (adoHFSD) impairs hippocampus (HPC)-dependent memory in rodents. These results were obtained in males only and it remains to evaluate whether adoHFSD has similar effect in females. Therefore, here, we investigated the effects of adoHFSD consumption on HPC-dependent contextual fear memory and associated brain activation in male and female mice. Exposure to adoHFSD increased fat mass accumulation and glucose levels in both males and females but impaired contextual fear memory only in males. Compared with females, contextual fear conditioning induced higher neuronal activation in the dorsal and ventral HPC (CA1 and CA3 subfields) as well as in the medial prefrontal cortex in males. Also, adoHFSD-fed males showed enhanced c-Fos expression in the dorsal HPC, particularly in the dentate gyrus, and in the basolateral amygdala compared with the other groups. Finally, chemogenetic inactivation of the dorsal HPC rescued adoHFSD-induced memory deficits in males. Our results suggest that males are more vulnerable to the effects of adoHFSD on HPC-dependent aversive memory than females, due to overactivation of the dorsal HPC.
dc.language.isoENen_US
dc.subject.enConditioning
dc.subject.enHippocampus
dc.subject.enHigh-fat
dc.subject.enSex
dc.subject.enFemales
dc.title.enObesogenic diet induces sex-specific alterations of contextual fear memory and associated hippocampal activity in mice
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/cercor/bhae254en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed38934712en_US
bordeaux.journalCerebral Cortexen_US
bordeaux.volume34en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cerebral%20Cortex&rft.date=2024-06&rft.volume=34&rft.issue=6&rft.au=N'DIAYE,%20Mat%C3%A9o&DUCOURNEAU,%20Eva-Gunnel&BAKOYIANNIS,%20Ioannis&POTIER,%20Myl%C3%A8ne&LAFENETRE,%20Pauline&rft.genre=article


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