Afficher la notice abrégée

Early movement restriction impairs the development of sensorimotor integration, motor skills and memory in rats: Towards a preclinical model of developmental coordination disorder?

dc.rights.licenseopenen_US
dc.contributor.authorKHALKI, Hanane
dc.contributor.authorLACERDA, Diego Cabral
dc.contributor.authorKAROUTCHI, Corane
dc.contributor.authorDELCOUR, Maxime
dc.contributor.authorDUPUIS, Orlane
dc.contributor.authorKOCHMANN, Marine
dc.contributor.authorBREZUN, Jean-Michel
dc.contributor.authorDUPONT, Erwan
dc.contributor.authorAMIN, Mamta
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDARNAUDÉRY, Muriel
dc.contributor.authorCANU, Marie-Hélène
dc.contributor.authorBARBE, Mary
dc.contributor.authorCOQ, Jacques-Olivier
dc.date.accessioned2025-03-20T08:19:23Z
dc.date.available2025-03-20T08:19:23Z
dc.date.issued2024-11
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205580
dc.description.abstractEnChildren with neurodevelopmental disorders, such as developmental coordination disorder (DCD), exhibit gross to fine sensorimotor impairments, reduced physical activity and interactions with the environment and people. This disorder co-exists with cognitive deficits, executive dysfunctions and learning impairments. Previously, we demonstrated in rats that limited amounts and atypical patterns of movements and somatosensory feedback during early movement restriction manifested in adulthood as degraded postural and locomotor abilities, and musculoskeletal histopathology, including muscle atrophy, hyperexcitability within sensorimotor circuitry and maladaptive cortical plasticity, leading to functional disorganization of the primary somatosensory and motor cortices in the absence of cortical histopathology. In this study, we asked how this developmental sensorimotor restriction (SMR) started to impact the integration of multisensory information and the emergence of sensorimotor reflexes in rats. We also questioned the enduring impact of SMR on motor activities, pain and memory. SMR led to deficits in the emergence of swimming and sensorimotor reflexes, the development of pain and altered locomotor patterns and posture with toe-walking, adult motor performance and night spontaneous activity. In addition, SMR induced exploratory hyperactivity, short-term impairments in object-recognition tasks and long-term deficits in object-location tasks. SMR rats displayed minor alterations in histological features of the hippocampus, entorhinal, perirhinal and postrhinal cortices yet no obvious changes in the prefrontal cortex. Taken all together, these results show similarities with the symptoms observed in children with DCD, although further exploration seems required to postulate whether developmental SMR corresponds to a rat model of DCD.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subject.enAnimal Model
dc.subject.enBehavior
dc.subject.enElectrophysiology
dc.subject.enNeurodevelopmental Disorder
dc.subject.enNeuromuscular
dc.title.enEarly movement restriction impairs the development of sensorimotor integration, motor skills and memory in rats: Towards a preclinical model of developmental coordination disorder?
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/ejn.16594en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed39523702en_US
bordeaux.journalEuropean Journal of Neuroscienceen_US
bordeaux.page1-21en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccCC BY-NCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Journal%20of%20Neuroscience&rft.date=2024-11&rft.spage=1-21&rft.epage=1-21&rft.au=KHALKI,%20Hanane&LACERDA,%20Diego%20Cabral&KAROUTCHI,%20Corane&DELCOUR,%20Maxime&DUPUIS,%20Orlane&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
NutriNeuro_Eur_J_Neuroscience_ ...
Taille:
2.760Mo
Format:
PDF
Voir/Ouvrir
Thumbnail
Nom:
license_rdf
Taille:
920octets
Format:
application/rdf+xml
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée