Biocompatible and Biodegradable Poly(trimethylene carbonate)-b-Poly (L-glutamic acid) Polymersomes: Size Control and Stability
dc.rights.license | open | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
dc.contributor.author | SANSON, Charles | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | LE MEINS, Jean-Francois | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | SCHATZ, Christophe | |
hal.structure.identifier | Laboratoire Léon Brillouin [LLB - UMR 12] | |
dc.contributor.author | BRÛLET, Annie | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
dc.contributor.author | SOUM, Alain | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | LECOMMANDOUX, Sebastien | |
dc.date.accessioned | 2020 | |
dc.date.available | 2020 | |
dc.date.created | 2010 | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0743-7463 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20555 | |
dc.description.abstractEn | Poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC-b-PGA) diblock copolymers have been synthesized by ring-opening polymerization (ROP) of gamma-benzyl-L-glutamate N-carboxyanhydride (BLG) initiated by amino functionalized PTMC and subsequent hydrogenation. Self-assembly in water gave well-defined vesicles which have been Studied combining light and neutron scattering techniques with electron microscopy imaging. The size and dispersity of vesicles have been tuned by varying preparation conditions, direct dissolution, or nanoprecipitation. In addition, PGA conformation could be reversibly manipulated as a function of environmental changes such as pH and ionic strength. Vesicles showed high tolerance and stability toward nonionic surfactant and pH due to a thick membrane and were revealed to be nonpermeable to water. Nevertheless, they can be rapidly degraded by enzymatic hydrolysis of the polycarbonate block. The ability to tune their size through the formation process, their stimuli responsiveness, their high stability, and their biodegradability make them suitable for biomedical applications. | |
dc.language.iso | en | |
dc.publisher | American Chemical Society | |
dc.subject.en | MICELLES | |
dc.subject.en | IN-VIVO | |
dc.subject.en | CIRCULAR-DICHROISM | |
dc.subject.en | LIGHT-SCATTERING | |
dc.subject.en | NERVE GUIDE | |
dc.subject.en | EPSILON-CAPROLACTONE POLYMER | |
dc.subject.en | BLOCK-COPOLYMER VESICLES | |
dc.subject.en | DIBLOCK COPOLYMERS | |
dc.subject.en | TRIMETHYLENE CARBONATE | |
dc.subject.en | NANOPARTICLE FORMATION | |
dc.title.en | Biocompatible and Biodegradable Poly(trimethylene carbonate)-b-Poly (L-glutamic acid) Polymersomes: Size Control and Stability | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1021/la902786t | |
dc.subject.hal | Chimie/Polymères | |
bordeaux.journal | Langmuir | |
bordeaux.page | 2751-2760 | |
bordeaux.volume | 26 | |
bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
bordeaux.issue | 4 | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-00652991 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-00652991v1 | |
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