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Biocompatible and Biodegradable Poly(trimethylene carbonate)-b-Poly (L-glutamic acid) Polymersomes: Size Control and Stability

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorSANSON, Charles
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLE MEINS, Jean-Francois
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSCHATZ, Christophe
hal.structure.identifierLaboratoire Léon Brillouin [LLB - UMR 12]
dc.contributor.authorBRÛLET, Annie
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorSOUM, Alain
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.created2010
dc.date.issued2010
dc.identifier.issn0743-7463
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20555
dc.description.abstractEnPoly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC-b-PGA) diblock copolymers have been synthesized by ring-opening polymerization (ROP) of gamma-benzyl-L-glutamate N-carboxyanhydride (BLG) initiated by amino functionalized PTMC and subsequent hydrogenation. Self-assembly in water gave well-defined vesicles which have been Studied combining light and neutron scattering techniques with electron microscopy imaging. The size and dispersity of vesicles have been tuned by varying preparation conditions, direct dissolution, or nanoprecipitation. In addition, PGA conformation could be reversibly manipulated as a function of environmental changes such as pH and ionic strength. Vesicles showed high tolerance and stability toward nonionic surfactant and pH due to a thick membrane and were revealed to be nonpermeable to water. Nevertheless, they can be rapidly degraded by enzymatic hydrolysis of the polycarbonate block. The ability to tune their size through the formation process, their stimuli responsiveness, their high stability, and their biodegradability make them suitable for biomedical applications.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enMICELLES
dc.subject.enIN-VIVO
dc.subject.enCIRCULAR-DICHROISM
dc.subject.enLIGHT-SCATTERING
dc.subject.enNERVE GUIDE
dc.subject.enEPSILON-CAPROLACTONE POLYMER
dc.subject.enBLOCK-COPOLYMER VESICLES
dc.subject.enDIBLOCK COPOLYMERS
dc.subject.enTRIMETHYLENE CARBONATE
dc.subject.enNANOPARTICLE FORMATION
dc.title.enBiocompatible and Biodegradable Poly(trimethylene carbonate)-b-Poly (L-glutamic acid) Polymersomes: Size Control and Stability
dc.typeArticle de revue
dc.identifier.doi10.1021/la902786t
dc.subject.halChimie/Polymères
bordeaux.journalLangmuir
bordeaux.page2751-2760
bordeaux.volume26
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue4
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00652991
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00652991v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Langmuir&rft.date=2010&rft.volume=26&rft.issue=4&rft.spage=2751-2760&rft.epage=2751-2760&rft.eissn=0743-7463&rft.issn=0743-7463&rft.au=SANSON,%20Charles&LE%20MEINS,%20Jean-Francois&SCHATZ,%20Christophe&BR%C3%9BLET,%20Annie&SOUM,%20Alain&rft.genre=article


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