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hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorSANSON, Charles
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLE MEINS, Jean-Francois
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSCHATZ, Christophe
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 1 LCPO : Polymerization Catalyses & Engineering
dc.contributor.authorSOUM, Alain
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.created2010
dc.date.issued2010
dc.identifier.issn1744-683X
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20554
dc.description.abstractEnWe have reported on a new type of thermotropic transition in synthetic diblock copolymer vesicles. Vesicles were self-assembled from a well-defined poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC22-b-PGA14, M(n) = 4.05*10(3) g mol(-1)) copolymer. PTMC(22) is a semi-crystalline hydrophobic block with a melting endotherm observed at 37 degrees C in the bulk copolymer and at 34-35 degrees C in the vesicular dispersions. This temperature transition, as observed by mDSC in the aqueous vesicular dispersions, arose from a variation of the PTMC chain packing inside the vesicular bilayer. A large range of vesicle sizes, from 100 nm to 5 mu m, was accessible by varying the experimental conditions to prepare the vesicles. Large vesicles were more sensitive to the melting transition due to a low membrane curvature and high hydrophobic block interactions. By many aspects, this transition presented strong analogies with the gel-to-liquid crystalline phase transition observed in liposomes. Vesicle budding and fission occurred when temperature was increased above the PTMC melting temperature and fusion events were observed when temperature was decreased. The fission process was certainly due to the creation of an excess area upon heating whereas fusion is due to membrane defects arising from variation in PTMC membrane packing. As a consequence, the size of the vesicles was found correlated to the crystalline state of the PTMC chains, its variation being fully reversible with the temperature.
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.subject.enCRYSTALLINE PHASE-TRANSITION
dc.subject.enBLOCK-COPOLYMERS
dc.subject.enDIPALMITOYLPHOSPHATIDYLCHOLINE VESICLES
dc.subject.enDIBLOCK COPOLYMERS
dc.subject.enBIOLOGICAL-MEMBRANES
dc.subject.enLIPID-BILAYERS
dc.subject.enACYL CHAINS
dc.subject.enMICELLES
dc.subject.enDISPERSIONS
dc.subject.enMORPHOLOGY
dc.title.enTemperature responsive poly(trimethylene carbonate)-block-poly(L-glutamic acid) copolymer: polymersomes fusion and fission
dc.typeArticle de revue
dc.identifier.doi10.1039/b924617g
dc.subject.halChimie/Polymères
bordeaux.journalSoft Matter
bordeaux.page1722-1730
bordeaux.volume6
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue8
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00653000
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00653000v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Soft%20Matter&rft.date=2010&rft.volume=6&rft.issue=8&rft.spage=1722-1730&rft.epage=1722-1730&rft.eissn=1744-683X&rft.issn=1744-683X&rft.au=SANSON,%20Charles&LE%20MEINS,%20Jean-Francois&SCHATZ,%20Christophe&SOUM,%20Alain&LECOMMANDOUX,%20Sebastien&rft.genre=article


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