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A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion

dc.rights.licenseopenen_US
dc.contributor.authorMONTANER, Mireia
dc.contributor.authorDENOM, Jessica
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorSIMON, Vincent
dc.contributor.authorJIANG, Wanqing
dc.contributor.authorHOLT, Marie K
dc.contributor.authorBRIERLEY, Daniel I
dc.contributor.authorROUCH, Claude
dc.contributor.authorFOPPEN, Ewout
dc.contributor.authorKASSIS, Nadim
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorJARRIAULT, David
dc.contributor.authorKHAN, Dawood
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorEYGRET, Louise
dc.contributor.authorMIFSUD, Francois
dc.contributor.authorHODSON, David J
dc.contributor.authorBROICHHAGEN, Johannes
dc.contributor.authorVAN OUDENHOVE, Lukas
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFIORAMONTI, Xavier
dc.contributor.authorGAULT, Victor
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCOTA, Daniela
dc.contributor.authorREIMANN, Frank
dc.contributor.authorGRIBBLE, Fiona M
dc.contributor.authorMIGRENNE-LI, Stephanie
dc.contributor.authorTRAPP, Stefan
dc.contributor.authorGURDEN, Hirac
dc.contributor.authorMAGNAN, Christophe
dc.date.accessioned2025-03-13T13:27:54Z
dc.date.available2025-03-13T13:27:54Z
dc.date.issued2024-08
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205493
dc.description.abstractEnGlucagon-like peptide 1 (GLP-1) stimulates insulin secretion and holds significant pharmacological potential. Nevertheless, the regulation of energy homeostasis by centrally-produced GLP-1 remains partially understood. Preproglucagon cells, known to release GLP-1, are found in the olfactory bulb (OB). We show that activating GLP-1 receptors (GLP-1R) in the OB stimulates insulin secretion in response to oral glucose in lean and diet-induced obese male mice. This is associated with reduced noradrenaline content in the pancreas and blocked by an α2-adrenergic receptor agonist, implicating functional involvement of the sympathetic nervous system (SNS). Inhibiting GABAA receptors in the paraventricular nucleus of the hypothalamus (PVN), the control centre of the SNS, abolishes the enhancing effect on insulin secretion induced by OB GLP-1R. Therefore, OB GLP-1-dependent regulation of insulin secretion relies on a relay within the PVN. This study provides evidence that OB GLP-1 signalling engages a top-down neural mechanism to control insulin secretion via the SNS.
dc.description.sponsorshipDéveloppment d'une infrastructure française distribuée coordonnéeen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.title.enA neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-024-51076-4en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed39138162en_US
bordeaux.journalNature Communicationsen_US
bordeaux.page6941en_US
bordeaux.volume15en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionINSERM
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.description.error
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2024-08&rft.volume=15&rft.spage=6941&rft.epage=6941&rft.au=MONTANER,%20Mireia&DENOM,%20Jessica&SIMON,%20Vincent&JIANG,%20Wanqing&HOLT,%20Marie%20K&rft.genre=article


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