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Mycoplasma pneumoniae infection in adult inpatients during the 2023-24 outbreak in France (MYCADO): a national, retrospective, observational study.

dc.rights.licenseopenen_US
dc.contributor.authorGAVAUD, Ariane
dc.contributor.authorHOLUB, Matthieu
dc.contributor.authorASQUIER-KHATI, Antoine
dc.contributor.authorFAURE, Karine
dc.contributor.authorLEAUTEZ-NAINVILLE, Sophie
dc.contributor.authorLE MOAL, Gwenael
dc.contributor.authorGOEHRINGER, François
dc.contributor.authorLUQUE PAZ, David
dc.contributor.authorARNOULD, Bérangère
dc.contributor.authorGERBER, Victor
dc.contributor.authorMARTIN-BLONDEL, Guillaume
dc.contributor.authorDECLERCK, Charles
dc.contributor.authorGAZAIGNES, Sandrine
dc.contributor.authorBLANCHI, Sophie
dc.contributor.authorLOUBET, Paul
dc.contributor.authorMROZEK, Natacha
dc.contributor.authorPERPOINT, Thomas
dc.contributor.authorCRESTA, Melanie
dc.contributor.authorMAILHE, Morgane
dc.contributor.authorBLEIBTREU, Alexandre
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorCAZANAVE, Charles
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorBÉBÉAR, Cécile
dc.contributor.authorPOURCHER, Valérie
dc.contributor.authorTUBACH, Florence
dc.contributor.authorPALICH, Romain
dc.date.accessioned2025-02-25T09:20:24Z
dc.date.available2025-02-25T09:20:24Z
dc.date.issued2025-02-19
dc.identifier.issn1474-4457en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205186
dc.description.abstractEnAn epidemic of Mycoplasma pneumoniae infection has been observed in France since September, 2023. We aimed to describe the characteristics of adults hospitalised for M pneumoniae infection and identify factors associated with severe outcomes of infection. MYCADO is a retrospective observational study including adults hospitalised for 24 h or more in 76 hospitals in France for a M pneumoniae infection between Sept 1, 2023, and Feb 29, 2024. Clinical, laboratory, and imaging data were collected from medical records. We identified factors associated with severe outcomes of infection, defined as a composite of intensive care unit (ICU) admission or in-hospital death, using multivariable logistic regression. 1309 patients with M pneumoniae infection were included: 718 (54·9%) were men and 591 (45·1%) were women; median age was 43 years (IQR 31-63); 288 (22·0%) had chronic respiratory failure; 423 (32·3%) had cardiovascular comorbidities; and 105 (8·0%) had immunosuppression. The most common symptoms were cough (1098 [83·9%]), fever (1023 [78·2%]), dyspnoea (948 [72·4%]), fatigue (550 [42·0%]), expectorations (473 [36·1%]), headache (211 [16·1%]), arthromyalgia (253 [19·3%]), ear, nose, and throat symptoms (202 [15·4%]), diarrhoea (138 [10·5%]), and vomiting (132 [10·1%]). 156 (11·9%) of 1309 patients had extra-respiratory manifestations, including 36 (2·8%) with erythema multiforme, 19 (1·5%) with meningoencephalitis, 44 (3·4%) with autoimmune haemolytic anaemia, and 17 (1·3%) with myocarditis. The median hospital stay was 8 days (IQR 6-11). 424 (32·4%) patients had a severe outcome of infection, including 415 (31·7%) who were admitted to the ICU and 28 (2·1%) who died in hospital. Those more likely to present with severe outcomes of infection were patients with hypertension, obesity, chronic liver failure, extra-respiratory manifestations, pulmonary alveolar consolidation or bilateral involvement on CT scan, as well as elevated inflammatory markers, lymphopenia or neutrophilic polynucleosis, and those who did not versus did receive any antibiotic active against M pneumoniae before admission. This national, observational study highlighted unexpected, atypical radiological presentations, a high proportion of transfers to the ICU, and an association between severity and delayed administration of effective antibiotics. This should remind clinicians that no radiological presentation can rule out M pneumoniae infection, and encourage them to reassess patients early after prescribing a β-lactam, or even to discuss prescribing macrolides as first-line treatment in the context of an epidemic. None. For the French translation of the abstract see Supplementary Materials section.
dc.language.isoENen_US
dc.title.enMycoplasma pneumoniae infection in adult inpatients during the 2023-24 outbreak in France (MYCADO): a national, retrospective, observational study.
dc.title.alternativeLancet Infect Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/S1473-3099(24)00805-3en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.identifier.pubmed39986287en_US
bordeaux.journalThe Lancet Infectious Diseasesen_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04965051
hal.version1
hal.date.transferred2025-02-25T09:20:27Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
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