Association between herpes simplex virus infection and Alzheimer's disease biomarkers: analysis within the MAPT trial.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LINARD, Morgane | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | GARRIGUE, Isabelle
IDREF: 12258953X | |
| hal.structure.identifier | Centre d'Epidémiologie et de Recherche en santé des POPulations [CERPOP] | |
| dc.contributor.author | VELLAS, Bruno | |
| hal.structure.identifier | Centre d'Epidémiologie et de Recherche en santé des POPulations [CERPOP] | |
| dc.contributor.author | COLEY, Nicola | |
| dc.contributor.author | ZETTERBERG, Henrik | |
| dc.contributor.author | BLENNOW, Kaj | |
| dc.contributor.author | ASHTON, Nicholas James | |
| hal.structure.identifier | Toulouse NeuroImaging Center [ToNIC] | |
| dc.contributor.author | PAYOUX, Pierre | |
| hal.structure.identifier | Toulouse NeuroImaging Center [ToNIC] | |
| dc.contributor.author | SALABERT, Anne-Sophie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DARTIGUES, Jean-François | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | MAZERE, Joachim | |
| hal.structure.identifier | Centre d'Epidémiologie et de Recherche en santé des POPulations [CERPOP] | |
| dc.contributor.author | ANDRIEU, Sandrine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HELMER, Catherine | |
| dc.date.accessioned | 2025-02-25T09:19:51Z | |
| dc.date.available | 2025-02-25T09:19:51Z | |
| dc.date.issued | 2025-01-18 | |
| dc.identifier.issn | 2045-2322 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/205185 | |
| dc.description.abstractEn | In vitro and animal studies have suggested that inoculation with herpes simplex virus 1 (HSV-1) can lead to amyloid deposits, hyperphosphorylation of tau, and/or neuronal loss. Here, we studied the association between HSV-1 and Alzheimer's disease biomarkers in humans. Our sample included 182 participants at risk of cognitive decline from the Multidomain Alzheimer Preventive Trial who had HSV-1 plasma serology and an amyloid PET scan. Plasma Aβ42/40 ratio, neurofilament light chain and p-tau181 were also available for a sub-sample of participants. Multivariate linear regressions were performed and stratified by APOE4 genotype. The median age was 74.0 years, 85.2% were infected with HSV-1. Infected participants tended to have a lower cortical amyloid load than uninfected participants (β = -0.08, p = 0.06), especially those suspected of reactivating HSV-1 most frequently (i.e. with a high anti-HSV-1 IgG level; n = 58, β = -0.09 p = 0.04). After stratification, the association was only significant in APOE4 carriers (n = 43, β = -0.21 p = 0.01). No association was found with the plasma biomarkers. The trend toward lower cortical amyloid load in HSV-1-infected participants was unexpected given the pre-existing literature and may be explained either by a modified immune response in HSV-1 infected subjects which could favour the clearance of amyloid deposits or by a selection bias. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Humans | |
| dc.subject.en | Alzheimer Disease | |
| dc.subject.en | Male | |
| dc.subject.en | Female | |
| dc.subject.en | Biomarkers | |
| dc.subject.en | Aged | |
| dc.subject.en | Herpes Simplex | |
| dc.subject.en | tau Proteins | |
| dc.subject.en | Herpesvirus 1 | |
| dc.subject.en | Human | |
| dc.subject.en | Amyloid beta-Peptides | |
| dc.subject.en | Apolipoprotein E4 | |
| dc.subject.en | Positron-Emission Tomography | |
| dc.subject.en | Aged | |
| dc.subject.en | 80 and over | |
| dc.subject.en | Middle Aged | |
| dc.subject.en | Cognitive Dysfunction | |
| dc.title.en | Association between herpes simplex virus infection and Alzheimer's disease biomarkers: analysis within the MAPT trial. | |
| dc.title.alternative | Sci Rep | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41598-024-84583-x | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| dc.identifier.pubmed | 39825066 | en_US |
| bordeaux.journal | Scientific Reports | en_US |
| bordeaux.page | 2362 | en_US |
| bordeaux.volume | 15 | en_US |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04965047 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-02-25T09:19:55Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
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