Afficher la notice abrégée

Orthostatic hypotension and cognitive impairment: Systematic review and meta-analysis of longitudinal studies

dc.rights.licenseopenen_US
dc.contributor.authorDUVAL, Guillaume T
dc.contributor.authorRAUD, Eve
dc.contributor.authorGOHIER, Hugo
dc.contributor.authorDRAME, Moustapha
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTABUE TEGUO, Maturin
ORCID: 0000-0002-1211-5660
IDREF: 175400768
dc.contributor.authorANNWEILER, Cedric
dc.date.accessioned2025-02-21T12:33:04Z
dc.date.available2025-02-21T12:33:04Z
dc.date.issued2024-07-01
dc.identifier.issn1873-4111en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205103
dc.description.abstractEnThe association between cognitive disorders and orthostatic hypotension (OH) has been empirically explored, but the results have been divergent, casting doubt on the presence and direction of the association. The objective of this meta-analysis was to systematically review and quantitatively synthesize the association of OH and cognitive function, specifically mean score on the Mini-Mental State Examination (MMSE), cognitive impairment and incident dementia. A Medline search was conducted in May 2022 with no date limit, using the MeSH terms "orthostatic hypotension" OR "orthostatic intolerance" OR "hypotension" combined with the Mesh terms "cognitive dysfunction" OR "Alzheimer disease" OR "dementia" OR "cognition disorder" OR "neurocognitive disorder" OR "cognition" OR "neuropsychological test". Of the 746 selected studies, 15 longitudinal studies met the selection criteria, of which i) 5 studies were eligible for meta-analysis of mean MMSE score comparison, ii) 5 studies for the association of OH and cognitive impairment, and iii) 6 studies for the association between OH and incident dementia. The pooled effect size in fixed-effects meta-analysis was: i) -0.25 (-0.42; -0.07) for the mean MMSE score, which indicates that the MMSE score was lower for those with OH; ii) OR (95 % CI) = 1.278 (1.162; 1.405), P < 0.0001, indicating a 28 % greater risk of cognitive impairment for those with OH at baseline; and iii) HR (95 % CI) = 1.267 (1.156; 1.388), P < 0.0001, indicating a 27 % greater risk of incident dementia for those with OH at baseline. Patients with OH had a lower MMSE score and higher risk of cognitive impairment and incident dementia in this meta-analysis of longitudinal studies. This study confirmed the presence of an association between OH and cognitive disorders in older adults.
dc.language.isoENen_US
dc.subject.enCognition
dc.subject.enOlder Adults
dc.subject.enOrthostatic Hypotension
dc.subject.enMeta-Analysis
dc.title.enOrthostatic hypotension and cognitive impairment: Systematic review and meta-analysis of longitudinal studies
dc.title.alternativeMaturitasen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.maturitas.2023.107866en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38604094en_US
bordeaux.journalMaturitasen_US
bordeaux.page107866en_US
bordeaux.volume185en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamACTIVE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Maturitas&amp;rft.date=2024-07-01&amp;rft.volume=185&amp;rft.spage=107866&amp;rft.epage=107866&amp;rft.eissn=1873-4111&amp;rft.issn=1873-4111&amp;rft.au=DUVAL,%20Guillaume%20T&amp;RAUD,%20Eve&amp;GOHIER,%20Hugo&amp;DRAME,%20Moustapha&amp;TABUE%20TEGUO,%20Maturin&amp;rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée