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dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorNGUYEN, Minh Ngoc
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorLEBARBÉ, Thomas
dc.contributor.authorZOUANI, Omar Farouk
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorPICHAVANT, Loïc
dc.contributor.authorDURRIEU, Marie-Christine
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 1 LCPO : Polymerization Catalyses & Engineering
dc.contributor.authorHÉROGUEZ, Valérie
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2012
dc.identifier.issn1525-7797
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20494
dc.description.abstractEnThis work reports on the synthesis of titanium bone implants functionalized with nanoparticles (NPs) containing Arg-Gly-Asp-Cys peptide (RGDC) and shows the adhesion behavior of cells seeded on these materials. RGDC peptides were first: conjugated to a norbornenyl-poly(ethylene oxide) macromonomer (Nb-PEO). Then, functional NPs with a size of similar to 300 nm and constituted of polynorbornene core surrounded by poly(ethylene oxide) shell were prepared by ring-opening metathesis polymerization in dispersed medium. The grafting density of these NPs on the titanium surface is up to 2 NPs.mu m(-2) (80 pmol of RGDC per cm(-2) of NP surface). Cell adhesion was evaluated using preosteoblast cells (MC3T3-E1). Results of cells cultured for 24 h showed that materials grafted with NPs functionalized with RGDC peptides enhance specific cell adhesion and can create filopodia-like among NP sites by stressing the cells.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enBIOMATERIALS
dc.subject.enVIVO
dc.subject.enIMPLANTS
dc.subject.enOPENING METATHESIS POLYMERIZATION
dc.subject.enIN-VITRO
dc.subject.enBONE-FORMATION
dc.subject.enPEPTIDES
dc.subject.enSURFACES
dc.subject.enDIFFERENTIATION
dc.subject.enHYDROGELS
dc.title.enImpact of RGD Nanopatterns Grafted onto Titanium on Osteoblastic Cell Adhesion
dc.typeArticle de revue
dc.identifier.doi10.1021/bm201812u
dc.subject.halChimie/Polymères
bordeaux.journalBiomacromolecules
bordeaux.page896-904
bordeaux.volume13
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue3
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00744166
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00744166v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomacromolecules&rft.date=2012&rft.volume=13&rft.issue=3&rft.spage=896-904&rft.epage=896-904&rft.eissn=1525-7797&rft.issn=1525-7797&rft.au=NGUYEN,%20Minh%20Ngoc&LEBARB%C3%89,%20Thomas&ZOUANI,%20Omar%20Farouk&PICHAVANT,%20Lo%C3%AFc&DURRIEU,%20Marie-Christine&rft.genre=article


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