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Impact of RGD Nanopatterns Grafted onto Titanium on Osteoblastic Cell Adhesion
| dc.rights.license | open | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| dc.contributor.author | NGUYEN, Minh Ngoc | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| dc.contributor.author | LEBARBÉ, Thomas | |
| dc.contributor.author | ZOUANI, Omar Farouk | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| dc.contributor.author | PICHAVANT, Loïc | |
| dc.contributor.author | DURRIEU, Marie-Christine | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 1 LCPO : Polymerization Catalyses & Engineering | |
| dc.contributor.author | HÉROGUEZ, Valérie | |
| dc.date.accessioned | 2020 | |
| dc.date.available | 2020 | |
| dc.date.issued | 2012 | |
| dc.identifier.issn | 1525-7797 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20494 | |
| dc.description.abstractEn | This work reports on the synthesis of titanium bone implants functionalized with nanoparticles (NPs) containing Arg-Gly-Asp-Cys peptide (RGDC) and shows the adhesion behavior of cells seeded on these materials. RGDC peptides were first: conjugated to a norbornenyl-poly(ethylene oxide) macromonomer (Nb-PEO). Then, functional NPs with a size of similar to 300 nm and constituted of polynorbornene core surrounded by poly(ethylene oxide) shell were prepared by ring-opening metathesis polymerization in dispersed medium. The grafting density of these NPs on the titanium surface is up to 2 NPs.mu m(-2) (80 pmol of RGDC per cm(-2) of NP surface). Cell adhesion was evaluated using preosteoblast cells (MC3T3-E1). Results of cells cultured for 24 h showed that materials grafted with NPs functionalized with RGDC peptides enhance specific cell adhesion and can create filopodia-like among NP sites by stressing the cells. | |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society | |
| dc.subject.en | BIOMATERIALS | |
| dc.subject.en | VIVO | |
| dc.subject.en | IMPLANTS | |
| dc.subject.en | OPENING METATHESIS POLYMERIZATION | |
| dc.subject.en | IN-VITRO | |
| dc.subject.en | BONE-FORMATION | |
| dc.subject.en | PEPTIDES | |
| dc.subject.en | SURFACES | |
| dc.subject.en | DIFFERENTIATION | |
| dc.subject.en | HYDROGELS | |
| dc.title.en | Impact of RGD Nanopatterns Grafted onto Titanium on Osteoblastic Cell Adhesion | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1021/bm201812u | |
| dc.subject.hal | Chimie/Polymères | |
| bordeaux.journal | Biomacromolecules | |
| bordeaux.page | 896-904 | |
| bordeaux.volume | 13 | |
| bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
| bordeaux.issue | 3 | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-00744166 | |
| hal.version | 1 | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-00744166v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomacromolecules&rft.date=2012&rft.volume=13&rft.issue=3&rft.spage=896-904&rft.epage=896-904&rft.eissn=1525-7797&rft.issn=1525-7797&rft.au=NGUYEN,%20Minh%20Ngoc&LEBARB%C3%89,%20Thomas&ZOUANI,%20Omar%20Farouk&PICHAVANT,%20Lo%C3%AFc&DURRIEU,%20Marie-Christine&rft.genre=article |
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