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SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

dc.rights.licenseopenen_US
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
hal.structure.identifierBasque Research and Technology Alliance [BRTA]
dc.contributor.authorLACHIONDO-ORTEGA, Sofia
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
hal.structure.identifierBasque Research and Technology Alliance [BRTA]
hal.structure.identifierUniversidad de Extremadura - University of Extremadura [UEX]
hal.structure.identifierBiofisika Institute (CSIC, UPV/EHU), 48940 Leioa,
dc.contributor.authorREJANO-GORDILLO, Claudia
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
hal.structure.identifierCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas = Biomedical Research Network Center for Liver and Digestive Diseases [Madrid] [CIBERehd]
dc.contributor.authorSIMON, Jorge
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
dc.contributor.authorLOPITZ-OTSOA, Fernando
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
dc.contributor.authorC. DELGADO, Teresa
dc.contributor.authorMAZAN-MAMCZARZ, Krystyna
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
dc.contributor.authorGOIKOETXEA-USANDIZAGA, Naroa
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
dc.contributor.authorZAPATA-PAVAS, L. Estefanía
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
dc.contributor.authorGARCÍA-DEL RÍO, Ana
hal.structure.identifierUniversità degli Studi di Padova = University of Padua [Unipd]
dc.contributor.authorGUERRA, Pietro
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
dc.contributor.authorPEÑA-SANFÉLIX, Patricia
hal.structure.identifierInstituto Maimonides de Investigación Biomédica de Cordoba [IMIBIC]
dc.contributor.authorHERMÁN-SÁNCHEZ, Natalia
hal.structure.identifierUniversidad Miguel Hernández [Elche] [UMH]
hal.structure.identifierUniversity of Medicine Greifswald
dc.contributor.authorAL-ABDULLA, Ruba
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
dc.contributor.authorFERNANDEZ-RODRÍGUEZ, Carmen
hal.structure.identifierCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas = Biomedical Research Network Center for Liver and Digestive Diseases [Madrid] [CIBERehd]
hal.structure.identifierUniversidad Pública de Navarra [Espagne] = Public University of Navarra [UPNA]
dc.contributor.authorAZKARGORTA, Mikel
hal.structure.identifierScientific Research Centre 'Isla de la Cartuja' (cicCartuja)
dc.contributor.authorVELÁZQUEZ-CRUZ, Alejandro
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGUYON, Joris
hal.structure.identifierUniversidad del País Vasco [Espainia] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne] [UPV / EHU]
dc.contributor.authorMARTÍN, César
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
dc.contributor.authorZALAMEA, Juan
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
dc.contributor.authorEGIA-MENDIKUTE, Leire
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
dc.contributor.authorSANZ-PARRA, Arantza
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
dc.contributor.authorSERRANO-MACIÁ, Marina
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
dc.contributor.authorGONZÁLEZ-RECIO, Irene
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
dc.contributor.authorGONZALEZ-LOPEZ, Monika
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
dc.contributor.authorMARTÍNEZ-CRUZ, Luis
hal.structure.identifierUniversità degli Studi di Padova = University of Padua [Unipd]
dc.contributor.authorPONTISSO, Patrizia
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
dc.contributor.authorARANSAY, Ana
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
dc.contributor.authorBARRIO, Rosa
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
dc.contributor.authorSUTHERLAND, James
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
hal.structure.identifierIkerbasque - Basque Foundation for Science
dc.contributor.authorABRESCIA, Nicola
hal.structure.identifierCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas = Biomedical Research Network Center for Liver and Digestive Diseases [Madrid] [CIBERehd]
dc.contributor.authorELORTZA, Félix
hal.structure.identifierIcahn School of Medicine at Mount Sinai [New York] [MSSM]
dc.contributor.authorLUJAMBIO, Amaia
hal.structure.identifierCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas = Biomedical Research Network Center for Liver and Digestive Diseases [Madrid] [CIBERehd]
hal.structure.identifierIkerbasque - Basque Foundation for Science
hal.structure.identifierUniversidad Pública de Navarra [Espagne] = Public University of Navarra [UPNA]
hal.structure.identifierBioDonostia Health Research Institute = Instituto de Investigación Sanitaria Biodonostia
dc.contributor.authorBANALES, Jesus
hal.structure.identifierInstituto Maimonides de Investigación Biomédica de Cordoba [IMIBIC]
dc.contributor.authorLUQUE, Raúl
hal.structure.identifierInstituto Maimonides de Investigación Biomédica de Cordoba [IMIBIC]
dc.contributor.authorGAHETE, Manuel
hal.structure.identifierCenter for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne) [CIC bioGUNE]
hal.structure.identifierIkerbasque - Basque Foundation for Science
dc.contributor.authorPALAZÓN, Asís
hal.structure.identifierCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas = Biomedical Research Network Center for Liver and Digestive Diseases [Madrid] [CIBERehd]
hal.structure.identifierCenter for Applied Medical Research [Plamplona] [CIMA]
hal.structure.identifierNavarra Institute for Health Research / Instituto de Investigación Sanitaria de Navarra [IdiSNA]
dc.contributor.authorAVILA, Matias
hal.structure.identifierCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas = Biomedical Research Network Center for Liver and Digestive Diseases [Madrid] [CIBERehd]
hal.structure.identifierInstituto de Investigación Biomédica de Salamanca [IBSAL]
dc.contributor.authorG. MARIN, Jose
dc.contributor.authorDE, Supriyo
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorDAUBON, Thomas
hal.structure.identifierScientific Research Centre 'Isla de la Cartuja' (cicCartuja)
dc.contributor.authorDÍAZ-QUINTANA, Antonio
hal.structure.identifierScientific Research Centre 'Isla de la Cartuja' (cicCartuja)
dc.contributor.authorDÍAZ-MORENO, Irene
dc.contributor.authorGOROSPE, Myriam
hal.structure.identifierLaboratoire de chimie de coordination [LCC]
hal.structure.identifierInstitut de pharmacologie et de biologie structurale [IPBS]
dc.contributor.authorRODRIGUEZ, Manuel S
hal.structure.identifierCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas = Biomedical Research Network Center for Liver and Digestive Diseases [Madrid] [CIBERehd]
dc.contributor.authorMARTÍNEZ-CHANTAR, María
dc.date.accessioned2025-02-06T14:05:16Z
dc.date.available2025-02-06T14:05:16Z
dc.date.issued2024-03-26
dc.identifier.issn2211-1247en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/204739
dc.description.abstractEnThe posttranslational modification of proteins critically influences many biological processes and is a key mechanism that regulates the function of the RNA-binding protein Hu antigen R (HuR), a hub in liver cancer. Here, we show that HuR is SUMOylated in the tumor sections of patients with hepatocellular carcinoma in contrast to the surrounding tissue, as well as in human cell line and mouse models of the disease. SUMOylation of HuR promotes major cancer hallmarks, namely proliferation and invasion, whereas the absence of HuR SUMOylation results in a senescent phenotype with dysfunctional mitochondria and endoplasmic reticulum. Mechanistically, SUMOylation induces a structural rearrangement of the RNA recognition motifs that modulates HuR binding affinity to its target RNAs, further modifying the transcriptomic profile toward hepatic tumor progression. Overall, SUMOylation constitutes a mechanism of HuR regulation that could be potentially exploited as a therapeutic strategy for liver cancer.
dc.language.isoENen_US
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enELAVL1
dc.subject.enSUMO
dc.subject.enPTMs
dc.subject.enSenescence
dc.subject.enHCC
dc.title.enSUMOylation controls Hu antigen R posttranscriptional activity in liver cancer
dc.title.alternativeCell Rep.en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.celrep.2024.113924en_US
dc.subject.halSciences du Vivant [q-bio]/Canceren_US
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique [q-bio.GN]en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Hépatologie et Gastroentérologieen_US
dc.identifier.pubmed38507413en_US
bordeaux.journalCell Reportsen_US
bordeaux.page113924en_US
bordeaux.volume43en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamAHEAD_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04522023
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Reports&rft.date=2024-03-26&rft.volume=43&rft.issue=3&rft.spage=113924&rft.epage=113924&rft.eissn=2211-1247&rft.issn=2211-1247&rft.au=LACHIONDO-ORTEGA,%20Sofia&REJANO-GORDILLO,%20Claudia&SIMON,%20Jorge&LOPITZ-OTSOA,%20Fernando&C.%20DELGADO,%20Teresa&rft.genre=article


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