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Efficacy and Safety of Fluocinolone Acetonide Implant (Iluvien®) in Postoperative Cystoid Macular Edema: ILUCYD study

dc.rights.licenseopenen_US
dc.contributor.authorMOTLOCH, K.
dc.contributor.authorCOUTURIER, A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELYFER, Marie-Noelle
dc.contributor.authorVASSEUR, V.
dc.contributor.authorWOLFF, B.
dc.contributor.authorISSA, M.
dc.contributor.authorDOT, C.
dc.contributor.authorWEBER, M.
dc.contributor.authorCOMET, A.
dc.contributor.authorHITZL, W.
dc.contributor.authorGARCHER, C. P. C.
dc.contributor.authorKODJIKIAN, L.
dc.contributor.authorTADAYONI, R.
dc.date.accessioned2025-02-06T08:52:21Z
dc.date.available2025-02-06T08:52:21Z
dc.date.issued2024-06-01
dc.date.conference2024-05-05
dc.identifier.issn0146-0404en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/204730
dc.description.abstractEnPurpose : Postoperative cystoid macular edema (PCME) is a common complication after vitreoretinal and cataract surgery with chronic or recurrent cases posing a significant therapeutic challenge. The aim of this study was to report the efficacy and safety of sustained-release fluocinolone acetonide (FAc) 0.19 mg intravitreal implant (Iluvien ®) in the treatment of chronic PCME. Methods : A retrospective multicentric study was conducted in a real-world setting in tertiary care centers in France. Eyes with chronic PCME after cataract or either multiple or single vitreoretinal surgeries, previously treated with multiple injections of intravitreal dexamethasone (DEX) implant (Ozurdex®), and then treated with FAc-implant were included. Best corrected visual acuity (BCVA) and central retinal thickness (CRT) were assessed as primary endpoints over the follow-up of 12 months. Main secondary endpoints included increase in intraocular pressure (IOP) and other adverse events, proportion of patients maintaining BCVA of at least 20/40, proportion of patients needing additional non-study treatment and OCT-markers associated with better BCVA. Results : 21 eyes from 21 patients were included. The mean baseline BCVA was 0.37 ± 0.23 logMAR and increased to 0.25 ± 0.18 logMAR at month 12 (p=0.0008). The mean baseline CRT was 425.9 ± 133.6 µm and decreased to 316.9 ± 67.0 µm by month 12 (p=0.0002). The mean IOP was 13.2 ± 3.7 mmHg at baseline and 14.73 ± 4.45 mmHg at month 12 (p=0.22). The proportion of eyes with BCVA of at least 20/40 increased from 52% at baseline to 82% at month 12 (p=0.007). At 3 months the odds of reaching BCVA ≥ 20/40 were higher in eyes with intact external limiting membrane. An additional therapy with DEX-implant was delivered in 8 eyes (38.1%). The number of the DEX-implant per year was lower after FAc implantation (mean of 1.5 ± 0.5 DEX-implant/year) compared to the year preceding FAc implantation (mean of 3.05 ± 1.65; p=0.001). Conclusions : FAc implant in eyes with chronic PCME showed lasting anatomic and functional improvement with a good safety profile. Final BCVA was correlated with intact outer retinal layers on SD-OCT. Furthermore, FAc implant allowed reduction of the treatment burden over 12 months.
dc.language.isoENen_US
dc.title.enEfficacy and Safety of Fluocinolone Acetonide Implant (Iluvien®) in Postoperative Cystoid Macular Edema: ILUCYD study
dc.typeCommunication dans un congrèsen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.volume65en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.conference.title2024 ARVO Annual Meetingen_US
bordeaux.countryusen_US
bordeaux.title.proceedingInvestigative Ophthalmology & Visual Scienceen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.conference.citySeattleen_US
hal.identifierhal-04931906
hal.version1
hal.date.transferred2025-02-06T08:52:25Z
hal.proceedingsouien_US
hal.conference.organizerARVOen_US
hal.conference.end2024-05-09
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2024-06-01&rft.volume=65&rft.issue=7&rft.eissn=0146-0404&rft.issn=0146-0404&rft.au=MOTLOCH,%20K.&COUTURIER,%20A.&DELYFER,%20Marie-Noelle&VASSEUR,%20V.&WOLFF,%20B.&rft.genre=unknown


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