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X‐chromosome-wide association study for Alzheimer’s disease

dc.rights.licenseopenen_US
hal.structure.identifierFacteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
dc.contributor.authorLE BORGNE, Julie
dc.contributor.authorGOMEZ, Lissette
dc.contributor.authorHEIKKINEN, Sami
dc.contributor.authorAMIN, Najaf
dc.contributor.authorAHMAD, Shahzad
dc.contributor.authorCHOI, Seung Hoan
dc.contributor.authorBIS, Joshua
dc.contributor.authorGRENIER-BOLEY, Benjamin
dc.contributor.authorRODRIGUEZ, Omar Garcia
dc.contributor.authorKLEINEIDAM, Luca
dc.contributor.authorYOUNG, Juan
dc.contributor.authorTRIPATHI, Kumar Parijat
dc.contributor.authorWANG, Lily
dc.contributor.authorVARMA, Achintya
dc.contributor.authorCAMPOS-MARTIN, Rafael
dc.contributor.authorVAN DER LEE, Sven
dc.contributor.authorDAMOTTE, Vincent
dc.contributor.authorDE ROJAS, Itziar
dc.contributor.authorPALMAL, Sagnik
dc.contributor.authorLIPTON, Richard
dc.contributor.authorREIMAN, Eric
dc.contributor.authorMCKEE, Ann
dc.contributor.authorDE JAGER, Philip
dc.contributor.authorBUSH, William
dc.contributor.authorSMALL, Scott
dc.contributor.authorLEVEY, Allan
dc.contributor.authorSAYKIN, Andrew
dc.contributor.authorFOROUD, Tatiana
dc.contributor.authorALBERT, Marilyn
dc.contributor.authorHYMAN, Bradley
dc.contributor.authorPETERSEN, Ronald
dc.contributor.authorYOUNKIN, Steven
dc.contributor.authorSANO, Mary
dc.contributor.authorWISNIEWSKI, Thomas
dc.contributor.authorVASSAR, Robert
dc.contributor.authorSCHNEIDER, Julie
dc.contributor.authorHENDERSON, Victor
dc.contributor.authorROBERSON, Erik
dc.contributor.authorDECARLI, Charles
dc.contributor.authorLAFERLA, Frank
dc.contributor.authorBREWER, James
dc.contributor.authorSWERDLOW, Russell
dc.contributor.authorVAN ELDIK, Linda
dc.contributor.authorHAMILTON-NELSON, Kara
dc.contributor.authorPAULSON, Henry
dc.contributor.authorNAJ, Adam
dc.contributor.authorLOPEZ, Oscar
dc.contributor.authorCHUI, Helena
dc.contributor.authorCRANE, Paul
dc.contributor.authorGRABOWSKI, Thomas
dc.contributor.authorKUKULL, Walter
dc.contributor.authorASTHANA, Sanjay
dc.contributor.authorCRAFT, Suzanne
dc.contributor.authorSTRITTMATTER, Stephen
dc.contributor.authorCRUCHAGA, Carlos
dc.contributor.authorLEVERENZ, James
dc.contributor.authorGOATE, Alison
dc.contributor.authorKAMBOH, M. Ilyas
dc.contributor.authorGEORGE-HYSLOP, Peter St
dc.contributor.authorVALLADARES, Otto
dc.contributor.authorKUZMA, Amanda
dc.contributor.authorCANTWELL, Laura
dc.contributor.authorRIEMENSCHNEIDER, Matthias
dc.contributor.authorMORRIS, John
dc.contributor.authorSLIFER, Susan
dc.contributor.authorDALMASSO, Carolina
dc.contributor.authorCASTILLO, Atahualpa
dc.contributor.authorKÜÇÜKALI, Fahri
dc.contributor.authorPETERS, Oliver
dc.contributor.authorSCHNEIDER, Anja
dc.contributor.authorDICHGANS, Martin
dc.contributor.authorRUJESCU, Dan
dc.contributor.authorSCHERBAUM, Norbert
dc.contributor.authorDECKERT, Jürgen
dc.contributor.authorRIEDEL-HELLER, Steffi
dc.contributor.authorHAUSNER, Lucrezia
dc.contributor.authorMOLINA-PORCEL, Laura
dc.contributor.authorDÜZEL, Emrah
dc.contributor.authorGRIMMER, Timo
dc.contributor.authorWILTFANG, Jens
dc.contributor.authorHEILMANN-HEIMBACH, Stefanie
dc.contributor.authorMOEBUS, Susanne
dc.contributor.authorTEGOS, Thomas
dc.contributor.authorSCARMEAS, Nikolaos
dc.contributor.authorDOLS-ICARDO, Oriol
dc.contributor.authorMORENO, Fermin
dc.contributor.authorPÉREZ-TUR, Jordi
dc.contributor.authorBULLIDO, María
dc.contributor.authorPASTOR, Pau
dc.contributor.authorSÁNCHEZ-VALLE, Raquel
dc.contributor.authorÁLVAREZ, Victoria
dc.contributor.authorBOADA, Mercè
dc.contributor.authorGARCÍA-GONZÁLEZ, Pablo
dc.contributor.authorPUERTA, Raquel
dc.contributor.authorMIR, Pablo
dc.contributor.authorREAL, Luis
dc.contributor.authorPIÑOL-RIPOLL, Gerard
dc.contributor.authorGARCÍA-ALBERCA, Jose María
dc.contributor.authorROYO, Jose Luís
dc.contributor.authorRODRIGUEZ-RODRIGUEZ, Eloy
dc.contributor.authorSOININEN, Hilkka
dc.contributor.authorDE MENDONÇA, Alexandre
dc.contributor.authorMEHRABIAN, Shima
dc.contributor.authorTRAYKOV, Latchezar
dc.contributor.authorHORT, Jakub
dc.contributor.authorVYHNALEK, Martin
dc.contributor.authorTHOMASSEN, Jesper Qvist
dc.contributor.authorPIJNENBURG, Yolande
dc.contributor.authorHOLSTEGE, Henne
dc.contributor.authorVAN SWIETEN, John
dc.contributor.authorRAMAKERS, Inez
dc.contributor.authorVERHEY, Frans
dc.contributor.authorSCHELTENS, Philip
dc.contributor.authorGRAFF, Caroline
dc.contributor.authorPAPENBERG, Goran
dc.contributor.authorGIEDRAITIS, Vilmantas
hal.structure.identifierCentre National de Recherche en Génomique Humaine [CNRGH]
dc.contributor.authorBOLAND, Anne
hal.structure.identifierCentre National de Recherche en Génomique Humaine [CNRGH]
dc.contributor.authorDELEUZE, Jean-François
dc.contributor.authorNICOLAS, Gael
dc.contributor.authorDUFOUIL, Carole
dc.contributor.authorPASQUIER, Florence
dc.contributor.authorHANON, Olivier
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorGRÜNBLATT, Edna
dc.contributor.authorPOPP, Julius
dc.contributor.authorGHIDONI, Roberta
dc.contributor.authorGALIMBERTI, Daniela
dc.contributor.authorAROSIO, Beatrice
dc.contributor.authorMECOCCI, Patrizia
dc.contributor.authorSOLFRIZZI, Vincenzo
dc.contributor.authorPARNETTI, Lucilla
dc.contributor.authorSQUASSINA, Alessio
dc.contributor.authorTREMOLIZZO, Lucio
dc.contributor.authorBORRONI, Barbara
dc.contributor.authorNACMIAS, Benedetta
dc.contributor.authorSPALLAZZI, Marco
dc.contributor.authorSERIPA, Davide
dc.contributor.authorRAINERO, Innocenzo
dc.contributor.authorDANIELE, Antonio
dc.contributor.authorBOSSÙ, Paola
dc.contributor.authorMASULLO, Carlo
dc.contributor.authorROSSI, Giacomina
dc.contributor.authorJESSEN, Frank
dc.contributor.authorFERNANDEZ, Victoria
dc.contributor.authorKEHOE, Patrick Gavin
dc.contributor.authorFRIKKE-SCHMIDT, Ruth
dc.contributor.authorTSOLAKI, Magda
dc.contributor.authorSÁNCHEZ-JUAN, Pascual
dc.contributor.authorSLEEGERS, Kristel
dc.contributor.authorINGELSSON, Martin
dc.contributor.authorHAINES, Jonathan
dc.contributor.authorFARRER, Lindsay
dc.contributor.authorMAYEUX, Richard
dc.contributor.authorWANG, Li-San
dc.contributor.authorSIMS, Rebecca
dc.contributor.authorDESTEFANO, Anita
dc.contributor.authorSCHELLENBERG, Gerard
dc.contributor.authorSESHADRI, Sudha
dc.contributor.authorAMOUYEL, Philippe
dc.contributor.authorWILLIAMS, Julie
dc.contributor.authorVAN DER FLIER, Wiesje
dc.contributor.authorRAMIREZ, Alfredo
dc.contributor.authorPERICAK-VANCE, Margaret
dc.contributor.authorANDREASSEN, Ole
dc.contributor.authorVAN DUIJN, Cornelia
dc.contributor.authorHILTUNEN, Mikko
dc.contributor.authorRUIZ, Agustín
dc.contributor.authorDUPUIS, Josée
dc.contributor.authorMARTIN, Eden
dc.contributor.authorLAMBERT, Jean-Charles
dc.contributor.authorKUNKLE, Brian
dc.contributor.authorBELLENGUEZ, Céline
dc.date.accessioned2025-01-30T12:58:32Z
dc.date.available2025-01-30T12:58:32Z
dc.date.issued2024-12-04
dc.identifier.issn1359-4184en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/204662
dc.description.abstractEnDue to methodological reasons, the X-chromosome has not been featured in the major genome-wide association studies on Alzheimer’s Disease (AD). To address this and better characterize the genetic landscape of AD, we performed an in-depth X-Chromosome-Wide Association Study (XWAS) in 115,841 AD cases or AD proxy cases, including 52,214 clinically-diagnosed AD cases, and 613,671 controls. We considered three approaches to account for the different X-chromosome inactivation (XCI) states in females, i.e. random XCI, skewed XCI, and escape XCI. We did not detect any genome-wide significant signals (P ≤ 5 × 10 − 8 ) but identified seven X-chromosome-wide significant loci (P ≤ 1.6 × 10 − 6 ). The index variants were common for the Xp22.32, FRMPD4, DMD and Xq25 loci, and rare for the WNK3 , PJA1 , and DACH2 loci. Overall, this well-powered XWAS found no genetic risk factors for AD on the non-pseudoautosomal region of the X-chromosome, but it identified suggestive signals warranting further investigations.
dc.description.sponsorshipIdentification of personalized inflammatory profiles of aging and senescence which are modified specifically by risk factors of dementia modulating the pre-clinical speed of dementia progression.en_US
dc.language.isoENen_US
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.title.enX‐chromosome-wide association study for Alzheimer’s disease
dc.title.alternativeMol Psychiatryen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41380-024-02838-5en_US
dc.subject.halSciences du Vivant [q-bio]/Génétique/Génétique humaineen_US
dc.identifier.pubmed39633006en_US
bordeaux.journalMolecular Psychiatryen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation pour la Recherche sur Alzheimeren_US
bordeaux.identifier.funderIDSigrid Juséliuksen Säätiöen_US
bordeaux.identifier.funderIDResearch Council of Finlanden_US
bordeaux.identifier.funderIDNational Institutes of Healthen_US
bordeaux.import.sourcehal
hal.identifierhal-04911762
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular%20Psychiatry&rft.date=2024-12-04&rft.eissn=1359-4184&rft.issn=1359-4184&rft.au=LE%20BORGNE,%20Julie&GOMEZ,%20Lissette&HEIKKINEN,%20Sami&AMIN,%20Najaf&AHMAD,%20Shahzad&rft.genre=article


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