LE BORGNE, Julie; GOMEZ, Lissette; HEIKKINEN, Sami; AMIN, Najaf; AHMAD, Shahzad; CHOI, Seung Hoan; BIS, Joshua; GRENIER-BOLEY, Benjamin; RODRIGUEZ, Omar Garcia; KLEINEIDAM, Luca; YOUNG, Juan; TRIPATHI, Kumar Parijat; WANG, Lily; VARMA, Achintya; CAMPOS-MARTIN, Rafael; VAN DER LEE, Sven; DAMOTTE, Vincent; DE ROJAS, Itziar; PALMAL, Sagnik; LIPTON, Richard; REIMAN, Eric; MCKEE, Ann; DE JAGER, Philip; BUSH, William; SMALL, Scott; LEVEY, Allan; SAYKIN, Andrew; FOROUD, Tatiana; ALBERT, Marilyn; HYMAN, Bradley; PETERSEN, Ronald; YOUNKIN, Steven; SANO, Mary; WISNIEWSKI, Thomas; VASSAR, Robert; SCHNEIDER, Julie; HENDERSON, Victor; ROBERSON, Erik; DECARLI, Charles; LAFERLA, Frank; BREWER, James; SWERDLOW, Russell; VAN ELDIK, Linda; HAMILTON-NELSON, Kara; PAULSON, Henry; NAJ, Adam; LOPEZ, Oscar; CHUI, Helena; CRANE, Paul; GRABOWSKI, Thomas; KUKULL, Walter; ASTHANA, Sanjay; CRAFT, Suzanne; STRITTMATTER, Stephen; CRUCHAGA, Carlos; LEVERENZ, James; GOATE, Alison; KAMBOH, M. Ilyas; GEORGE-HYSLOP, Peter St; VALLADARES, Otto; KUZMA, Amanda; CANTWELL, Laura; RIEMENSCHNEIDER, Matthias; MORRIS, John; SLIFER, Susan; DALMASSO, Carolina; CASTILLO, Atahualpa; KÜÇÜKALI, Fahri; PETERS, Oliver; SCHNEIDER, Anja; DICHGANS, Martin; RUJESCU, Dan; SCHERBAUM, Norbert; DECKERT, Jürgen; RIEDEL-HELLER, Steffi; HAUSNER, Lucrezia; MOLINA-PORCEL, Laura; DÜZEL, Emrah; GRIMMER, Timo; WILTFANG, Jens; HEILMANN-HEIMBACH, Stefanie; MOEBUS, Susanne; TEGOS, Thomas; SCARMEAS, Nikolaos; DOLS-ICARDO, Oriol; MORENO, Fermin; PÉREZ-TUR, Jordi; BULLIDO, María; PASTOR, Pau; SÁNCHEZ-VALLE, Raquel; ÁLVAREZ, Victoria; BOADA, Mercè; GARCÍA-GONZÁLEZ, Pablo; PUERTA, Raquel; MIR, Pablo; REAL, Luis; PIÑOL-RIPOLL, Gerard; GARCÍA-ALBERCA, Jose María; ROYO, Jose Luís; RODRIGUEZ-RODRIGUEZ, Eloy; SOININEN, Hilkka; DE MENDONÇA, Alexandre; MEHRABIAN, Shima; TRAYKOV, Latchezar; HORT, Jakub; VYHNALEK, Martin; THOMASSEN, Jesper Qvist; PIJNENBURG, Yolande; HOLSTEGE, Henne; VAN SWIETEN, John; RAMAKERS, Inez; VERHEY, Frans; SCHELTENS, Philip; GRAFF, Caroline; PAPENBERG, Goran; GIEDRAITIS, Vilmantas; BOLAND, Anne; DELEUZE, Jean-François; NICOLAS, Gael; DUFOUIL, Carole; PASQUIER, Florence; HANON, Olivier; DEBETTE, Stephanie; GRÜNBLATT, Edna; POPP, Julius; GHIDONI, Roberta; GALIMBERTI, Daniela; AROSIO, Beatrice; MECOCCI, Patrizia; SOLFRIZZI, Vincenzo; PARNETTI, Lucilla; SQUASSINA, Alessio; TREMOLIZZO, Lucio; BORRONI, Barbara; NACMIAS, Benedetta; SPALLAZZI, Marco; SERIPA, Davide; RAINERO, Innocenzo; DANIELE, Antonio; BOSSÙ, Paola; MASULLO, Carlo; ROSSI, Giacomina; JESSEN, Frank; FERNANDEZ, Victoria; KEHOE, Patrick Gavin; FRIKKE-SCHMIDT, Ruth; TSOLAKI, Magda; SÁNCHEZ-JUAN, Pascual; SLEEGERS, Kristel; INGELSSON, Martin; HAINES, Jonathan; FARRER, Lindsay; MAYEUX, Richard; WANG, Li-San; SIMS, Rebecca; DESTEFANO, Anita; SCHELLENBERG, Gerard; SESHADRI, Sudha; AMOUYEL, Philippe; WILLIAMS, Julie; VAN DER FLIER, Wiesje; RAMIREZ, Alfredo; PERICAK-VANCE, Margaret; ANDREASSEN, Ole; VAN DUIJN, Cornelia; HILTUNEN, Mikko; RUIZ, Agustín; DUPUIS, Josée; MARTIN, Eden; LAMBERT, Jean-Charles; KUNKLE, Brian; BELLENGUEZ, Céline

doi:10.1038/s41380-024-02838-5

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BPH_MolPsychiatry_2024_LeBorgne.pdf (4.170Mb)

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LE BORGNE, Julie
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]

GOMEZ, Lissette

HEIKKINEN, Sami

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Molecular Psychiatry. 2024-12-04

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Due to methodological reasons, the X-chromosome has not been featured in the major genome-wide association studies on Alzheimer’s Disease (AD). To address this and better characterize the genetic landscape of AD, we performed an in-depth X-Chromosome-Wide Association Study (XWAS) in 115,841 AD cases or AD proxy cases, including 52,214 clinically-diagnosed AD cases, and 613,671 controls. We considered three approaches to account for the different X-chromosome inactivation (XCI) states in females, i.e. random XCI, skewed XCI, and escape XCI. We did not detect any genome-wide significant signals (P ≤ 5 × 10 − 8 ) but identified seven X-chromosome-wide significant loci (P ≤ 1.6 × 10 − 6 ). The index variants were common for the Xp22.32, FRMPD4, DMD and Xq25 loci, and rare for the WNK3 , PJA1 , and DACH2 loci. Overall, this well-powered XWAS found no genetic risk factors for AD on the non-pseudoautosomal region of the X-chromosome, but it identified suggestive signals warranting further investigations.< Leer menos

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https://oskar-bordeaux.fr/handle/20.500.12278/204662

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http://dx.doi.org/10.1038/s41380-024-02838-5

Proyecto ANR

Identification of personalized inflammatory profiles of aging and senescence which are modified specifically by risk factors of dementia modulating the pre-clinical speed of dementia progression.

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Bordeaux Population Health Research Center (BPH) - UMR 1219

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X‐chromosome-wide association study for Alzheimer’s disease

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