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Easy and effective method to produce functionalized particles for cellular uptake

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorCOLLETTE, Floraine
hal.structure.identifierSynthèse et réactivité des substances naturelles [SRSN]
dc.contributor.authorDELATOUCHE, Régis
hal.structure.identifierCentre de Recherche en Cancérologie Nantes-Angers [CRCNA]
dc.contributor.authorBLANQUART, Christophe
hal.structure.identifierCentre de Recherche en Cancérologie Nantes-Angers [CRCNA]
dc.contributor.authorGUEUGNON, Fabien
hal.structure.identifierCentre de Recherche en Cancérologie Nantes-Angers [CRCNA]
dc.contributor.authorGREGOIRE, Marc
hal.structure.identifierSynthèse et réactivité des substances naturelles [SRSN]
dc.contributor.authorBERTRAND, Philippe
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 1 LCPO : Polymerization Catalyses & Engineering
dc.contributor.authorHÉROGUEZ, Valérie
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2012
dc.identifier.issn0887-624X
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20461
dc.description.abstractEnIn this contribution, a versatile approach for the synthesis of functionalized particles for drug delivery is presented, using two nonaggressive standardized procedures. The first procedure considered is the functionalization of an azido-terminated α-norbornenyl poly(ethylene oxide) (PEO) macromonomer with an alkyne-containing active molecule via the copper catalyzed azide alkyne cycloaddition, click type reaction. The functionalized macromonomer is then polymerized by Ring-Opening Metathesis Polymerization (ROMP) in dispersion to form functionalized particles. The second procedure consists in synthesizing particles by ROMP in dispersed media of norbornene with azido-terminated α-norbornenyl PEO macromonomer. The ROMP was initiated by the first generation Grubbs catalyst. Such functionalized core-shell particles have stealthy properties due to their PEO shell and can be viewed as universal nanocarriers on which any alkyne-modified active molecule can be grafted by click chemistry. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013
dc.language.isoen
dc.publisherWiley
dc.subject.enpoly(ethylene oxide)
dc.subject.encore-shell particles
dc.subject.enclick chemistry
dc.subject.enbiocompatibility
dc.subject.enpolynorbornene
dc.subject.enROMP
dc.title.enEasy and effective method to produce functionalized particles for cellular uptake
dc.typeArticle de revue
dc.identifier.doi10.1002/pola.26357
dc.subject.halChimie/Polymères
bordeaux.journalJournal of Polymer Science Part A: Polymer Chemistry
bordeaux.page176-189
bordeaux.volume51
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue1
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00758913
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00758913v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Polymer%20Science%20Part%20A:%20Polymer%20Chemistry&rft.date=2012&rft.volume=51&rft.issue=1&rft.spage=176-189&rft.epage=176-189&rft.eissn=0887-624X&rft.issn=0887-624X&rft.au=COLLETTE,%20Floraine&DELATOUCHE,%20R%C3%A9gis&BLANQUART,%20Christophe&GUEUGNON,%20Fabien&GREGOIRE,%20Marc&rft.genre=article


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