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Population variation and prognostic potential of gut antibiotic resistome

hal.structure.identifierUniversity of Turku
dc.contributor.authorPÄRNÄNEN, Katariina
hal.structure.identifierUniversity of Turku
hal.structure.identifierNational Public Health Institute [Finland] [THL]
dc.contributor.authorRUUSKANEN, M.
hal.structure.identifierUniversity of Turku
hal.structure.identifierPleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE]
dc.contributor.authorSOMMERIA-KLEIN, G.
hal.structure.identifierUniversity of Turku
dc.contributor.authorLAITINEN, V.
hal.structure.identifierUniversity of Turku
dc.contributor.authorKANTANEN, P.
hal.structure.identifierCambridge Baker Systems Genomics Initiative
hal.structure.identifierMonash University [Melbourne]
hal.structure.identifierLa Trobe University [Melbourne]
hal.structure.identifierUniversity of Melbourne
hal.structure.identifierBaker Heart and Diabetes Institute (AUSTRALIA)
dc.contributor.authorMÉRIC, G.
hal.structure.identifierBaker Heart and Diabetes Institute (AUSTRALIA)
hal.structure.identifierUniversity of Melbourne
hal.structure.identifierCambridge Baker Systems Genomics Initiative
dc.contributor.authorGAZOLLA VOLPIANO, C.
hal.structure.identifierBaker Heart and Diabetes Institute (AUSTRALIA)
hal.structure.identifierUniversity of Melbourne
hal.structure.identifierDepartment of Public Health and Primary Care
hal.structure.identifierCambridge Baker Systems Genomics Initiative
dc.contributor.authorINOUYE, M.
hal.structure.identifierUniversity of California [San Diego] [UC San Diego]
dc.contributor.authorKNIGHT, R.
hal.structure.identifierNational Public Health Institute [Finland] [THL]
dc.contributor.authorSALOMAA, V.
hal.structure.identifierNational Public Health Institute [Finland] [THL]
hal.structure.identifierInstitute for Molecular Medicine Finland [Helsinki] [FIMM]
dc.contributor.authorHAVULINNA, A
hal.structure.identifierNational Public Health Institute [Finland] [THL]
hal.structure.identifierUniversity of Turku
dc.contributor.authorNIIRANEN, T.
hal.structure.identifierUniversity of Turku
dc.contributor.authorLAHTI, Leo
dc.date.accessioned2025-01-24T03:01:42Z
dc.date.available2025-01-24T03:01:42Z
dc.date.issued2024-08-08
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/204533
dc.description.abstractEn<div><p>The spread of antibiotic-resistance genes in bacteria has severely reduced the efficacy of antibiotics, now contributing to 1.3 million deaths annually. Despite the far-reaching epidemiological implications of this trend, the extent to which antimicrobial resistance load varies within human populations and the drivers that contribute most to this variation remain unclear. Here, we demonstrate in a representative cohort of 7,095 Finnish adults 1 that socio-demographic factors, lifestyle, and gut microbial community composition shape resistance selection and transmission processes. Antimicrobial resistance gene load was linked not only to prior use of antibiotics, as anticipated, but also to frequent consumption of fresh vegetables and poultry, two food groups previously reported to contain antibiotic-resistant bacteria. Interestingly, ARG load was not associated with high-fat and -sugar foods. Furthermore, antimicrobial resistance gene load was systematically higher in females and the generally healthier high-income demographics in urban and densely populated areas. Data from this prospective cohort with a 17-year follow-up suggests that the prognostic potential of antimicrobial resistome is comparable to blood pressure for mortality and sepsis. These findings highlight population-level risks and socio-demographic dimensions of antimicrobial resistance that are particularly relevant in the current context of global urbanization and middle-class growth.</p></div>
dc.language.isoen
dc.title.enPopulation variation and prognostic potential of gut antibiotic resistome
dc.typeDocument de travail - Pré-publication
dc.identifier.doi10.1101/2024.08.08.24311663
dc.subject.halSciences du Vivant [q-bio]/Ecologie, Environnement/Santé
dc.subject.halSciences de l'environnement/Environnement et Société
bordeaux.hal.laboratoriesBioGeCo (Biodiversité Gènes & Communautés) - UMR 1202*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionINRAE
hal.identifierhal-04908728
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04908728v1
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.date=2024-08-08&amp;rft.au=P%C3%84RN%C3%84NEN,%20Katariina&amp;RUUSKANEN,%20M.&amp;SOMMERIA-KLEIN,%20G.&amp;LAITINEN,%20V.&amp;KANTANEN,%20P.&amp;rft.genre=preprint


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