Mostrar el registro sencillo del ítem
Detection and Prevalence of Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium in Badalona, Spain
| dc.rights.license | open | en_US |
| dc.contributor.author | RIVAYA, Belén | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | LE ROY, Chloé | |
| dc.contributor.author | JORDANA-LLUCH, Elena | |
| dc.contributor.author | FERNÁNDEZ-RIVAS, Gema | |
| dc.contributor.author | CASAÑ, Cristina | |
| dc.contributor.author | GONZÁLEZ, Victoria | |
| dc.contributor.author | WANG-WANG, Jun Hao | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | BÉBÉAR, Cécile | |
| dc.contributor.author | MATAS, Lurdes | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | PEREYRE, Sabine | |
| dc.date.accessioned | 2025-01-14T07:47:42Z | |
| dc.date.available | 2025-01-14T07:47:42Z | |
| dc.date.issued | 2022-04-05 | |
| dc.identifier.issn | 2079-6382 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/204248 | |
| dc.description.abstractEn | Macrolide and fluoroquinolone resistance (MLr/FQr) in (MG) infections is concerning worldwide. Current guidelines recommend performing MLr detection in MG-positive cases to adjust antimicrobial therapy. We aimed to evaluate the usefulness of PCR followed by pyrosequencing for MLr detection in comparison with a one-step commercial assay and to assess the prevalence of MLr and FQr in Badalona, Spain. A total of 415 MG-positive samples by Allplex STI-7 (Seegene) were analyzed for MLr detection by pyrosequencing. From those, 179 samples were further analyzed for MG and MLr by ResistancePlus MG kit (SpeeDx) and 100 of them also for fluoroquinolone resistance (FQr) by sequencing the gene. Regarding MG detection, Allplex and Resistance Plus showed an overall agreement of 87%, but this value rose to 95.4% if we compare them for MLr detection. Prevalence of MLr was 23.1% in Badalona, but this rate increased to 73.7% in the HIV-positive patients cohort. FQr detection showed 3% of resistant strains. Pyrosequencing is a convenient and cheap technique for MLr detection, but one-step tools should be considered in high-throughput laboratories. Despite the fact that MLr remained moderate and FQr was low in our study, simultaneous MG and MLr detection would improve patient's management applying resistance-guided treatment strategies. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Mycoplasma genitalium; Spain; fluoroquinolone; macrolide; resistance | |
| dc.title.en | Detection and Prevalence of Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium in Badalona, Spain | |
| dc.title.alternative | Antibiotics (Basel) | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/antibiotics11040485 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Microbiologie et Parasitologie | en_US |
| dc.identifier.pubmed | 35453236 | en_US |
| bordeaux.journal | Antibiotics | en_US |
| bordeaux.volume | 11 | en_US |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04885150 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-01-14T07:47:45Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Antibiotics&rft.date=2022-04-05&rft.volume=11&rft.issue=4&rft.eissn=2079-6382&rft.issn=2079-6382&rft.au=RIVAYA,%20Bel%C3%A9n&LE%20ROY,%20Chlo%C3%A9&JORDANA-LLUCH,%20Elena&FERN%C3%81NDEZ-RIVAS,%20Gema&CASA%C3%91,%20Cristina&rft.genre=article |
