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Evidences that host genetic background more than the environment shapes the microbiota of the snail Bulinus truncatus , an intermediate host of Schistosoma species

hal.structure.identifierPhysiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]
dc.contributor.authorJAQUET, Mathilde
hal.structure.identifierInteractions Hôtes-Pathogènes-Environnements [IHPE]
dc.contributor.authorDOUCHET, Philippe
hal.structure.identifierInteractions Hôtes-Pathogènes-Environnements [IHPE]
dc.contributor.authorTOULZA, Eve
hal.structure.identifierMaladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle [MIVEGEC]
dc.contributor.authorLEFEVRE, Thierry
hal.structure.identifierVecteurs - Infections tropicales et méditerranéennes [VITROME]
dc.contributor.authorSENGHOR, Bruno
hal.structure.identifierInteractions Hôtes-Pathogènes-Environnements [IHPE]
dc.contributor.authorBOISSIER, Jérôme
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
dc.contributor.authorLEPAIS, Olivier
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
dc.contributor.authorCHANCEREL, Emilie
hal.structure.identifierInteractions Hôtes-Pathogènes-Environnements [IHPE]
dc.contributor.authorGOURBAL, Benjamin
hal.structure.identifierInteractions Hôtes-Pathogènes-Environnements [IHPE]
dc.contributor.authorREY, Olivier
dc.date.issued2024-11-01
dc.description.abstractEnMicrobiota are increasingly recognized as key players in regulating host biological functions, influencing both the ecology and evolution of organisms. However, the factors shaping microbiota diversity and structure in natural environments remain underexplored, especially the relative importance of host genetics versus environmental factors. In this study, we address this gap using the freshwater snail Bulinus truncatus , an intermediate host for some human and animal Schistosoma parasites, as a model species. We developed 31 new microsatellite markers to assess the population structure of B. truncatus across 9 sites in Senegal. We then applied metabarcoding to characterize the diversity and structure of individual snail bacterial microbiota and environmental communities associated with each sampling site using environmental DNA. We also used molecular diagnostics to determine trematode infection status of B. truncatus individuals. By integrating these data through multiple regression on distance matrices (MRM) analyses, we quantified the influence of B. truncatus population genetics, spatial distribution, environmental bacterial communities, and infection status on the snail’s microbiota structure. Our results show that the genetic structure of B. truncatus populations, and to a lower extent geographic distribution, are the main factors explaining the snail’s microbiota compositions. Neither the environmental bacterial communities nor trematode infection status significantly contributed to microbiota structure. A portion of the variance in microbiota composition remains unexplained, suggesting that additional ecological or intrinsic factors might be involved. These findings provide new insights into the drivers of microbiota structure in natural populations and highlight the complexity of host-microbiota-environment interactions. Key-words: Bulinus truncatus , Microbiota, Spatial structure, Population genetics, Trematodes, Multiple regressions on distance matrices
dc.language.isoen
dc.subject.enBulinus truncatus
dc.subject.enMicrobiota
dc.subject.enSpatial structure
dc.subject.enPopulation genetics
dc.subject.enTrematodes
dc.subject.enMultiple regressions on distance matrices
dc.title.enEvidences that host genetic background more than the environment shapes the microbiota of the snail Bulinus truncatus , an intermediate host of Schistosoma species
dc.typeDocument de travail - Pré-publication
dc.identifier.doi10.1101/2024.11.01.619350
dc.subject.halSciences du Vivant [q-bio]/Génétique/Génétique animale
dc.subject.halSciences du Vivant [q-bio]/Ecologie, Environnement/Interactions entre organismes
dc.subject.halSciences du Vivant [q-bio]/Génétique/Génétique des populations [q-bio.PE]
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie/Parasitologie
hal.identifierhal-04879778
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04879778v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2024-11-01&rft.au=JAQUET,%20Mathilde&DOUCHET,%20Philippe&TOULZA,%20Eve&LEFEVRE,%20Thierry&SENGHOR,%20Bruno&rft.genre=preprint


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