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Interdependence of plasma membrane nanoscale dynamics of a kinase and its cognate substrate underlies Arabidopsis response to viral infection

hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorJOLIVET, Marie-Dominique
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorDEROUBAIX, Anne-Flore
hal.structure.identifierInstitut des Sciences des Plantes de Paris-Saclay [IPS2 (UMR_9213 / UMR_1403)]
dc.contributor.authorBOUDSOCQ, Marie
hal.structure.identifierFakultät für Biologie = Faculty of Biology [Freiburg]
dc.contributor.authorABEL, Nikolaj
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorROCHER, Marion
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorROBBE, Terezinha
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorWATTELET-BOYER, Valérie
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorHUARD, Jennifer
hal.structure.identifierInstitut des Sciences des Plantes de Paris-Saclay [IPS2 (UMR_9213 / UMR_1403)]
dc.contributor.authorLEFEBVRE, Dorian
hal.structure.identifierMichigan State University [East Lansing]
dc.contributor.authorLU, Yi-Ju
hal.structure.identifierMichigan State University [East Lansing]
dc.contributor.authorDAY, Brad
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorSAIAS, Grégoire
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorAHMED, Jahed
hal.structure.identifierLRSV-Signalisation Cellulaire et Ubiquitination [LRSV-SCU]
dc.contributor.authorCOTELLE, Valérie
hal.structure.identifierGénétique et Amélioration des Fruits et Légumes [GAFL]
dc.contributor.authorGIOVINAZZO, Nathalie
hal.structure.identifierGénétique et Amélioration des Fruits et Légumes [GAFL]
dc.contributor.authorGALLOIS, Jean-Luc
hal.structure.identifierThe University of Tokyo [UTokyo]
dc.contributor.authorYAMAJI, Yasuyuki
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorGERMAN-RETANA, Sylvie
hal.structure.identifierZentrum für Molekularbiologie der Pflanzen [ZMBP]
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorGRONNIER, Julien
hal.structure.identifierCentre for Integrative Biological Signalling Studies [Freiburg] [CIBSS]
dc.contributor.authorOTT, Thomas
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorMONGRAND, Sébastien
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorGERMAIN, Véronique
dc.date.created2024-10-18
dc.date.issued2024-10-18
dc.description.abstractEnPlant viruses represent a risk to agricultural production and as only a few treatments exist, it is urgent to identify resistance mechanisms and factors. In plant immunity, plasma membrane (PM)-localized proteins play an essential role in sensing the extracellular threat presented by bacteria, fungi or herbivores. Viruses are intracellular pathogens and as such the role of the plant PM in detection and resistance against viruses is often overlooked. We investigated the role of the partially PM-bound Calcium-dependent protein kinase 3 (CPK3) in viral infection and we discovered that it displayed a specific ability to hamper viral propagation over CPK isoforms that are involved in immune response to extracellular pathogens. More and more evidence support that the lateral organization of PM proteins and lipids underlies signal transduction in plants. We showed here that CPK3 diffusion in the PM is reduced upon activation as well as upon viral infection and that such immobilization depended on its substrate, Remorin (REM1.2), a scaffold protein. Furthermore, we discovered that the viral infection induced a CPK3-dependent increase of REM1.2 PM diffusion. Such interdependence was also observable regarding viral propagation. This study unveils a complex relationship between a kinase and its substrate that contrasts with the commonly described co-stabilisation upon activation while it proposes a PM-based mechanism involved in decreased sensitivity to viral infection in plants.
dc.description.sponsorshipRégulation de la communication intercellulaire - le rôle de la phosphoprotéine REMORIN liée aux nanodomaines de la membrane plasmique
dc.description.sponsorshipSaclay Plant Sciences - ANR-10-LABX-0040
dc.language.isoen
dc.publishereLife Sciences Publication
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.title.enInterdependence of plasma membrane nanoscale dynamics of a kinase and its cognate substrate underlies Arabidopsis response to viral infection
dc.typeArticle de revue
dc.identifier.doi10.7554/eLife.90309.2
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journaleLife
bordeaux.pageRP90309
bordeaux.volume12
bordeaux.peerReviewedoui
hal.identifierhal-04873172
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04873172v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=eLife&rft.date=2024-10-18&rft.volume=12&rft.spage=RP90309&rft.epage=RP90309&rft.au=JOLIVET,%20Marie-Dominique&DEROUBAIX,%20Anne-Flore&BOUDSOCQ,%20Marie&ABEL,%20Nikolaj&ROCHER,%20Marion&rft.genre=article


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