Biocompatibility study of two diblock copolymeric nanoparticles for biomedical applications by in vitro toxicity
dc.rights.license | open | |
hal.structure.identifier | GAIKER Technological Centre | |
dc.contributor.author | GONI-DE-CERIO, Felipe | |
hal.structure.identifier | Tev Aviv Univ, Sackler Sch Med | |
dc.contributor.author | MARIANI, Valentina | |
hal.structure.identifier | Ahava Dead Sea Laboratories | |
hal.structure.identifier | Dead Sea-Arava Science Center [DSASC] | |
dc.contributor.author | COHEN, Dror | |
hal.structure.identifier | Tev Aviv Univ, Sackler Sch Med | |
dc.contributor.author | MADI, Lea | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
dc.contributor.author | THEVENOT, Julie | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
dc.contributor.author | DE OLIVEIRA, Hugo | |
hal.structure.identifier | JRC Institute for Health and Consumer Protection [IHCP] | |
dc.contributor.author | UBOLDI, Chiara | |
hal.structure.identifier | JRC Institute for Health and Consumer Protection [IHCP] | |
dc.contributor.author | GIUDETTI, Guido | |
hal.structure.identifier | JRC Institute for Health and Consumer Protection [IHCP] | |
dc.contributor.author | CORADEGHINI, Rosella | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | GARANGER, Elisabeth
IDREF: 089451740 | |
hal.structure.identifier | JRC Institute for Health and Consumer Protection [IHCP] | |
dc.contributor.author | ROSSI, François | |
hal.structure.identifier | Ahava Dead Sea Laboratories | |
dc.contributor.author | PORTUGAL-COHEN, Meital | |
hal.structure.identifier | Ahava Dead Sea Laboratories | |
dc.contributor.author | ORON, Miriam | |
hal.structure.identifier | Tev Aviv Univ, Sackler Sch Med | |
dc.contributor.author | KORENSTEIN, Rafi | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | LECOMMANDOUX, Sebastien | |
hal.structure.identifier | JRC Institute for Health and Consumer Protection [IHCP] | |
dc.contributor.author | PONTI, Jessica | |
hal.structure.identifier | GAIKER Technological Centre | |
dc.contributor.author | SUAREZ-MERINO, Blanca | |
hal.structure.identifier | GAIKER Technological Centre | |
dc.contributor.author | HEREDIA, Pedro | |
dc.date.accessioned | 2020 | |
dc.date.available | 2020 | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1388-0764 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20395 | |
dc.description.abstractEn | Drugs used for chemotherapy normally carry out adverse, undesired effects. Nanotechnology brings about new horizons to tackle cancer disease with a different strategy. One of the most promising approaches is the use of nanocarriers to transport active drugs. These nanocarriers need to have special properties to avoid immune responses and toxicity, and it is critical to study these effects. Nanocarriers may have different nature, but polypeptide-based copolymers have attracted considerable attention for their biocompatibility, controlled and slow biodegradability as well as low toxicity. Little has been done regarding specific nanocarriers toxicity. In this study, we performed a thorough toxicological study of two different block copolymer nanoparticles (NPs); poly(trimethylene carbonate)-block-poly(L-glutamic acid) (PTMC-b-PGA) and poly(ethylene glycol)-block-poly(gamma-benzyl-L-glutamate) (PEG-b-PBLG) with sizes between 113 and 131 nm. Low blood-serum-protein interaction was observed. Moreover, general toxicity assays and other endpoints (apoptosis or necrosis) showed good biocompatibility for both NPs. Reactive oxygen species increased in only two cell lines (HepG2 and TK6) in the presence of PTMC-b-PGA. Cytokine production study showed cytokine induction only in one cell line (A549). We also performed the same assays on human skin organ culture before and after UVB light treatment, with a moderate toxicity after treatment independent of NPs presence or absence. Interleukin 1 induction was also observed due to the combined effect of PEG-b-PBLG and UVB light irradiation. Future in vivo studies for biocompatibility and toxicity will provide more valuable information, but, so far, the findings presented here suggest the possibility of using these two NPs as nanocarriers for nanomedical applications, always taking into account the application procedure and the way in which they are implemented. | |
dc.language.iso | en | |
dc.publisher | Springer Verlag | |
dc.subject.en | Amphiphilic copolymers | |
dc.subject.en | Nanoparticles | |
dc.subject.en | In vitro toxicity | |
dc.subject.en | Cancer therapy | |
dc.subject.en | Nanoparticles toxicity | |
dc.subject.en | Biomedicine | |
dc.title.en | Biocompatibility study of two diblock copolymeric nanoparticles for biomedical applications by in vitro toxicity | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1007/s11051-013-2036-0 | |
dc.subject.hal | Chimie/Polymères | |
bordeaux.journal | Journal of Nanoparticle Research | |
bordeaux.page | 1-17, UNSP 2036 | |
bordeaux.volume | 15 | |
bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
bordeaux.issue | 11 | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-00926508 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-00926508v1 | |
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