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Clinical outcomes of pediatric kidney replacement therapy after childhood cancer-An ESPN/ERA Registry study

dc.rights.licenseopenen_US
dc.contributor.authorKAIJANSINKKO, Henna
dc.contributor.authorBONTHUIS, Marjolein
dc.contributor.authorJAHNUKAINEN, Kirsi
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jerome
dc.contributor.authorVIDAL, Enrico
dc.contributor.authorBAKKALOGLU, Sevcan A
dc.contributor.authorINWARD, Carol
dc.contributor.authorSINHA, Manish D
dc.contributor.authorROPERTO, Rosa M
dc.contributor.authorKUEHNI, Claudia E
dc.contributor.authorBIRO, Erika
dc.contributor.authorKWON, Theresa
dc.contributor.authorMOTA, Conceicao
dc.contributor.authorADAMS, Brigitte
dc.contributor.authorSZCZEPANSKA, Maria
dc.contributor.authorBIENIAS, Beata
dc.contributor.authorHOCKER, Britta
dc.contributor.authorFOMINA, Svitlana
dc.contributor.authorGJERSTAD, Ann Christin
dc.contributor.authorVONDRAK, Karel
dc.contributor.authorALPAY, Harika
dc.contributor.authorPLUMB, Lucy A
dc.contributor.authorHOMMEL, Kristine
dc.contributor.authorMOLCHANOVA, Maria S
dc.contributor.authorHUBMANN, Holger
dc.contributor.authorALONSO-MELGAR, Angel
dc.contributor.authorJAGER, Kitty J
dc.contributor.authorJAHNUKAINEN, Timo
dc.date.accessioned2024-12-13T13:29:31Z
dc.date.available2024-12-13T13:29:31Z
dc.date.issued2024-11-07
dc.identifier.issn1600-6143en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203936
dc.description.abstractEnCancer and its treatment may lead to kidney injury and need for kidney replacement therapy (KRT). We identified 287 pediatric KRT patients with a malignancy history from the ESPN/ERA Registry. Of these, 197 had cancer as a primary cause of KRT (group 1) and 90 had a malignancy diagnosis before KRT (group 2). Two matched controls without malignancy were randomly selected for each patient. Data were complemented with a questionnaire. Median time to kidney transplantation (KT) from KRT initiation was 2.4 (IQR: 1.5-4.7), 1.5 (IQR: 0.4-3.3), 3.6 (IQR: 1.3-Q3 not reached), and 1.1 (IQR: 0.3-3.6) years for group 1, their controls, group 2 and their controls, respectively. Overall 10-year mortality on KRT was higher among cancer patients vs. controls in group 1: 16% vs. 9% (aHR 2.02, 95% CI: 1.21-3.37) and in group 2: 23% vs. 14% (aHR 2.32, 95% CI: 1.11-4.85). In contrast, 10-year patient survival after first KT was comparable to controls (93% vs. 96%; 100% vs. 94%, in groups 1 and 2, respectively). In summary, childhood cancer survivors' KT was delayed, their overall mortality on KRT was increased, but once transplanted, their long-term outcome was similar to other KT recipients.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCancer
dc.subject.enChildren
dc.subject.enKidney Replacement Therapy
dc.subject.enKidney Transplantation
dc.subject.enMalignancy
dc.subject.enMortality
dc.title.enClinical outcomes of pediatric kidney replacement therapy after childhood cancer-An ESPN/ERA Registry study
dc.title.alternativeAm J Transplanten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ajt.2024.11.002en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39515759en_US
bordeaux.journalAmerican Journal of Transplantationen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDEuropean Renal Association-European Dialysis and Transplant Associationen_US
hal.identifierhal-04836547
hal.version1
hal.date.transferred2024-12-13T13:29:38Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=American%20Journal%20of%20Transplantation&rft.date=2024-11-07&rft.eissn=1600-6143&rft.issn=1600-6143&rft.au=KAIJANSINKKO,%20Henna&BONTHUIS,%20Marjolein&JAHNUKAINEN,%20Kirsi&HARAMBAT,%20Jerome&VIDAL,%20Enrico&rft.genre=article


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