Real-life use of temocillin in the treatment of bone and joint infections due to extended spectrum β-lactamase-producing Enterobacterales.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | LAHOUATI, Marin | |
| dc.contributor.author | BROUSSE, Xavier | |
| dc.contributor.author | DIAS MEIRELES, Vasco | |
| dc.contributor.author | RIGNOL, Laurine | |
| dc.contributor.author | BIENTZ, Léa | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | XUEREB, Fabien | |
| dc.contributor.author | DAUCHY, Frédéric-Antoine | |
| dc.date.accessioned | 2024-12-09T11:05:42Z | |
| dc.date.available | 2024-12-09T11:05:42Z | |
| dc.date.issued | 2024-12-01 | |
| dc.identifier.issn | 2632-1823 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/203796 | |
| dc.description.abstractEn | The aim of this study is to describe the real-life use of temocillin in bone and joint infections (BJI). We performed a monocentric retrospective study, including all patients treated by temocillin for a BJI due to extended spectrum β-lactamase-producing Enterobacterales (ESBL-E) between 1 January 2015 and 31 December 2022. Outcomes were evaluated at least 3 months after the end of antimicrobial treatment. Clinical cure was defined as the absence of recurrence of BJI during follow-up among patients who completed at least 7 days of temocillin. If the patient discontinued temocillin due to ineffectiveness, the outcome was considered to be unfavourable. Seventeen patients were treated with temocillin for ESBL-E associated BJI during the study period. Infections included osteomyelitis of the foot (7/17; 41.2%), femoral osteomyelitis (4/17; 23.5%), disco-vertebral infections (2/17; 11.8%), total knee prosthesis infections (2/17; 11.8%) and total hip prosthesis infections (2/17; 11.8%). All patients except one ( = 16) had surgical management of the infection. The main bacteria identified were the complex ( = 9) and ( = 5). The median daily dose was 6 g for a median duration of 42 days (IQR 14-42 days). The median duration of follow-up was 12 months (IQR 5.25-14.5). Overall, 12 patients completed at least 3 months of follow-up, and clinical cure was observed in eight of them (8/12; 66.7%). So far, this is the first report of BJI successfully treated with temocillin. This suggests that temocillin may be an alternative to treat BJI involving difficult-to-treat Enterobacterales when oral therapy is not available. | |
| dc.language.iso | EN | en_US |
| dc.title.en | Real-life use of temocillin in the treatment of bone and joint infections due to extended spectrum β-lactamase-producing Enterobacterales. | |
| dc.title.alternative | JAC Antimicrob Resist | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/jacamr/dlae171 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| dc.identifier.pubmed | 39512359 | en_US |
| bordeaux.journal | JAC-Antimicrobial Resistance | en_US |
| bordeaux.page | dlae171 | en_US |
| bordeaux.volume | 6 | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
| bordeaux.issue | 6 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04826727 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-12-09T11:05:44Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=JAC-Antimicrobial%20Resistance&rft.date=2024-12-01&rft.volume=6&rft.issue=6&rft.spage=dlae171&rft.epage=dlae171&rft.eissn=2632-1823&rft.issn=2632-1823&rft.au=LAHOUATI,%20Marin&BROUSSE,%20Xavier&DIAS%20MEIRELES,%20Vasco&RIGNOL,%20Laurine&BIENTZ,%20L%C3%A9a&rft.genre=article |
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