Course of brain damage following malignant hypertension.
| dc.rights.license | open | en_US |
| dc.contributor.author | LIEGEY, Jean Sebastien | |
| dc.contributor.author | CREMER, Antoine | |
| dc.contributor.author | LUCAS, Ludovic | |
| dc.contributor.author | GOSSE, Philippe | |
| dc.contributor.author | DEBEUGNY, Stéphane | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | RUBIN, Sebastien | |
| dc.contributor.author | DOUBLET, Julien | |
| dc.contributor.author | SIBON, Igor | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | BOULESTREAU, Romain | |
| dc.date.accessioned | 2024-12-09T10:47:20Z | |
| dc.date.available | 2024-12-09T10:47:20Z | |
| dc.date.issued | 2024-11-01 | |
| dc.identifier.issn | 1476-5527 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/203793 | |
| dc.description.abstractEn | Malignant hypertension (MHT) crisis triggers widespread microvascular damage, particularly in the brain. Despite recent MRI evidence highlighting acute cerebral injuries during MHT crises, follow-up data remain scarce. This study seeks to fill this gap by exploring how brain MRI markers evolve following acute MHT crisis management. We conducted a retrospective analysis of brain MRI data from MHT patients admitted to Bordeaux University Hospital between 2008 and 2022. Eligible patients had at least one follow-up MRI. Analysis blinded to clinical data was performed to identify markers of posterior reversible encephalopathy syndrome (PRES), acute stroke, cerebral hemorrhage, and microangiopathy. Out of 149 patients, 47 had follow-up MRIs. Most were male (72.3%) with a mean age of 48.2 ± 10.8 years. The median interval between initial and follow-up MRI was 228 days. Follow-up MRIs revealed new strokes in 10.6% of patients, cerebral hemorrhages in 4.3%, and no cases of PRES. Additionally, more patients exhibited chronic lacunar infarcts and/or microbleeds, with overall Fazekas scores remaining stable in 66.0%, improving in 31.9%, and worsening in 2.1%. Subgroup analyses based on blood pressure control or follow-up duration showed no significant differences in MRI markers. This study sheds light on the risk of new cerebrovascular events and the dynamic changes in brain MRI markers following acute MHT crisis management. Understanding these changes could lead to improved diagnosis, personalized treatment strategies, and proactive patient care for individuals with MHT. | |
| dc.language.iso | EN | en_US |
| dc.title.en | Course of brain damage following malignant hypertension. | |
| dc.title.alternative | J Hum Hypertens | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41371-024-00968-5 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| dc.identifier.pubmed | 39487319 | en_US |
| bordeaux.journal | Journal of Human Hypertension | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04826646 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-12-09T10:47:23Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Human%20Hypertension&rft.date=2024-11-01&rft.eissn=1476-5527&rft.issn=1476-5527&rft.au=LIEGEY,%20Jean%20Sebastien&CREMER,%20Antoine&LUCAS,%20Ludovic&GOSSE,%20Philippe&DEBEUGNY,%20St%C3%A9phane&rft.genre=article |
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