Course of immune thrombocytopenia according to the site of platelet destruction identified by indium-111 platelet scintigraphy.
| dc.rights.license | open | en_US |
| dc.contributor.author | DURAND, Pauline | |
| dc.contributor.author | POTTIER, Valérie | |
| dc.contributor.author | DEBORDEAUX, Frédéric | |
| dc.contributor.author | MESGUICH, Charles | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | DUFFAU, Pierre | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | LAZARO, Estibaliz | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | VIALLARD, Jean-François | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | RIVIÈRE, Etienne | |
| dc.date.accessioned | 2024-12-09T10:35:32Z | |
| dc.date.available | 2024-12-09T10:35:32Z | |
| dc.date.issued | 2024-10-15 | |
| dc.identifier.issn | 1365-2141 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/203790 | |
| dc.description.abstractEn | In primary immune thrombocytopenia (ITP), predictors of disease evolution and treatment response are needed. Data based on the site of platelet destruction are scarce. We performed a retrospective single-centre study of adult patients with primary ITP undergoing at least one Indium-111 platelet scintigraphy (IPS) between 2009 and 2018. Thirty-three patients had isolated hepatic platelet destruction (H-group), and 97 isolated splenic destruction (S-group). Median age at diagnosis (p < 0.001), proportion of associated cardiovascular (p < 0.001), organ-specific autoimmune diseases (p = 0.02), dependence on steroids (p = 0.003) and failure to rituximab (p = 0.01) were higher and relapse more frequent (p = 0.03) in H-group compared to non-splenectomized patients in S-group. Splenectomy was only performed in patients from S-group (as patients with hepatic sequestration are not splenectomized in our centre): 79% were in relapse-free remission at the end of a median 3.4-year post-IPS follow-up, 16% relapsed. In multivariate analyses, only a history of organ-specific autoimmune or inflammatory disease was significantly associated with hepatic sequestration (OR = 4.3, 95% CI = 1.2-15, p = 0.02). Patients with isolated hepatic sequestration were older, had more cardiovascular events and organ-specific autoimmune diseases, greater dependence on steroids, more relapses and a decreased response rate to rituximab suggesting an increased refractoriness to immunomodulatory therapies. Patients with isolated splenic sequestration responded well to splenectomy. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | TPO receptor agonists; immune thrombocytopenia; indium‐111 platelet scintigraphy; rituximab; sequestration pattern; splenectomy | |
| dc.title.en | Course of immune thrombocytopenia according to the site of platelet destruction identified by indium-111 platelet scintigraphy. | |
| dc.title.alternative | Br J Haematol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/bjh.19833 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| dc.identifier.pubmed | 39407432 | en_US |
| bordeaux.journal | British Journal of Haematology | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04826600 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-12-09T10:35:34Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=British%20Journal%20of%20Haematology&rft.date=2024-10-15&rft.eissn=1365-2141&rft.issn=1365-2141&rft.au=DURAND,%20Pauline&POTTIER,%20Val%C3%A9rie&DEBORDEAUX,%20Fr%C3%A9d%C3%A9ric&MESGUICH,%20Charles&DUFFAU,%20Pierre&rft.genre=article |
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