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ER-to-Golgi trafficking via a dynamic intermediate cis-Golgi tubular network in Arabidopsis

dc.rights.licenseopenen_US
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorFOUGÈRE, Louise
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorGRISON, Magali
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorLAQUEL, Patricia
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorMONTRAZI, Matheus
dc.contributor.authorCORDELIÈRES, Fabrice
dc.contributor.authorFERNÁNDEZ-MONREAL, Mónica
hal.structure.identifierBordeaux Imaging Center [BIC]
dc.contributor.authorPOUJOL, Christel
hal.structure.identifierThe University of Tokyo [UTokyo]
dc.contributor.authorUEMURA, Tomohiro
hal.structure.identifierLab Dev Cell Biol,Bunkyo Ku
dc.contributor.authorNAKANO, Akihiko
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorITO, Yoko
hal.structure.identifierCentre National de la Recherche Scientifique [CNRS]
dc.contributor.authorBOUTTÉ, Yohann
dc.date.accessioned2024-12-04T09:39:52Z
dc.date.available2024-12-04T09:39:52Z
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203686
dc.description.abstractEnEndoplasmic Reticulum (ER)-to-Golgi trafficking is a central process of the secretory system of eukaryotic cells that ensures proper spatiotemporal sorting of proteins and lipids1–5. However, the nature of the ER-Golgi Intermediate Compartments (ERGIC) and the molecular mechanisms mediating the transition between the ERGIC and the Golgi, as well as the universality of these processes amongst Eukaryotes, remain undiscovered. Here, we took advantage of the plant cell system in which the Golgi is highly dynamic and in close vicinity to the ER6–9. We discovered that the ERGIC is composed from at least two distinct subpopulations of cis-Golgi. A subpopulation is a reticulated tubulo-vesicular network mostly independent from the Golgi, highly dynamic at the ER-Golgi interface and crossed by ER-induced release of luminal cargos at early stage. Another subpopulation is more stable, cisterna-like and mostly associated to the Golgi. Our results identified that the generation and dynamics of the ER-Golgi intermediate tubulo-vesicular network is regulated by the acyl-chain length of sphingolipids as well as the contacts it establishes with existing Golgi cisternae. Our study is a major twist in the understanding of the Golgi by identifying that the ERGIC in plants is a Golgi-independent highly dynamic tubular network from which arise more stable cisternae-like Golgi structures. This novel model presents a mechanism for early secretory trafficking adapted to respond to developmental and environmental stimuli, including susceptibility or resistance to diseases, autophagy or cell-reprograming.
dc.description.sponsorshipMécanismes du pattern lipidique du réseau trans-Golgien (trans-Golgi Network) et rôles dans le tri des protéines, la polarité cellulaire et le développement des plantes - ANR-18-CE13-0025en_US
dc.description.sponsorshipImplication des lipides dans les mécanismes de régulation de l'organogenèse - ANR-21-CE13-0019en_US
dc.language.isoENen_US
dc.title.enER-to-Golgi trafficking via a dynamic intermediate cis-Golgi tubular network in Arabidopsis
dc.typeDocument de travail - Pré-publicationen_US
dc.identifier.doi10.1101/2023.10.27.563925en_US
dc.subject.halSciences du Vivant [q-bio]en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.institutionCNRSen_US
bordeaux.import.sourcehal
hal.identifierhal-04801327
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.subtypePrepublication/Preprinten_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=FOUG%C3%88RE,%20Louise&GRISON,%20Magali&LAQUEL,%20Patricia&MONTRAZI,%20Matheus&CORDELI%C3%88RES,%20Fabrice&rft.genre=preprint


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