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Time-restricted feeding prevents memory impairments induced by obesogenic diet consumption, via hippocampal thyroid hormone signaling

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorHELBLING, Jean-Christophe
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorGINIEIS, Rachel
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMORTESSAGNE, Pierre
hal.structure.identifierUniversidad San Pablo CEU
dc.contributor.authorRUIZ-GAYO, Mariano
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBAKOYIANNIS, Ioannis
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDUCOURNEAU, Eva-Gunnel
hal.structure.identifierPlateforme d'hébergement et d'exploration fonctionnelle (Chronobiotron)
dc.contributor.authorCIOCCA, Dominique
hal.structure.identifierPlateforme d'hébergement et d'exploration fonctionnelle (Chronobiotron)
dc.contributor.authorBOULETÉ, Illona-Marie
hal.structure.identifierInterdisciplinary Institute for Neuroscience / Institut interdisciplinaire de neurosciences [Bordeaux] [IINS]
dc.contributor.authorFAVEREAUX, Alexandre
hal.structure.identifierPlateforme d'hébergement et d'exploration fonctionnelle (Chronobiotron)
hal.structure.identifierInstitut des Neurosciences Cellulaires et Intégratives [INCI]
dc.contributor.authorCES, Aurélia
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMONTALBAN, Enrica
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
dc.contributor.authorJEANNETEAU, Freddy
hal.structure.identifierInstitut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement [INRAE]
dc.contributor.authorFERREIRA, Guillaume
hal.structure.identifierInstitut des Neurosciences Cellulaires et Intégratives [INCI]
dc.contributor.authorCHALLET, Etienne
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMOISAN, Marie-Pierre
dc.date.accessioned2024-11-21T08:49:10Z
dc.date.available2024-11-21T08:49:10Z
dc.date.issued2024-11
dc.identifier.issn2212-8778en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203394
dc.description.abstractEnObjective: The early consumption of calorie-rich diet disrupts circadian rhythms and has adverse effects on memory, yet the effects of timerestricted feeding (TRF) and the underlying molecular mechanisms are unknown. Here, we set out to identify the behavioral and molecular circadian rhythms disruptions generated by juvenile obesogenic diet consumption and their restoration by TRF in male mice.Methods: Metabolic rhythms were measured by indirect calorimetry and memory performances by behavioral tasks. Hippocampal translatome (pS6_TRAP), enrichment and co-regulated gene network analyses were conducted to identify the molecular pathways involved in memory impairments and their restoration by TRF. Differential exon usage analyses, mass spectrometry and pharmacological intervention were used to confirm thyroid hormone signaling involvement.Results: We show that four weeks of TRF restore the rhythmicity of metabolic parameters and prevents memory impairments in mice fed a high fat-high sucrose (HFS) diet since weaning, independently of body fat levels. Hippocampal translatome and differential exon usage analyses indicate that impaired memory of mice under ad libitum HFS diet is accompanied by reduced thyroid hormone signaling and altered expression of astrocytic genes regulating glutamate neurotransmission. TRF restored the diurnal expression variation of part of these genes and intrahippocampal infusion of T3, the active form of thyroid hormone, rescues memory performances and astrocytic gene expression of ad libitum HFS diet-fed mice.Conclusions: Thus, thyroid hormones contribute to the TRF positive effects on both metabolism and memory in mice fed an obesogenic diet, highlighting this nutritional approach as a powerful tool in addressing obesity brain comorbidities and paving the way for further mechanistic studies on hippocampal thyroid signaling.
dc.description.sponsorshipMémoire des Adolescents Obeses: Influences des Rythmes circadiens - ANR-21-CE14-0086en_US
dc.description.sponsorshipDéveloppment d'une infrastructure française distribuée coordonnée - ANR-10-INBS-0004en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enObesity
dc.subject.enCognition
dc.subject.enChrono-nutrition
dc.subject.enT3
dc.subject.enCircadian rhythms
dc.subject.enGene expression
dc.title.enTime-restricted feeding prevents memory impairments induced by obesogenic diet consumption, via hippocampal thyroid hormone signaling
dc.title.alternativeMol Metaben_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.molmet.2024.102061en_US
dc.subject.halSciences du Vivant [q-bio]/Alimentation et Nutritionen_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Endocrinologie et métabolismeen_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Sciences cognitivesen_US
dc.identifier.pubmed39515608en_US
bordeaux.journalMolecular metabolismen_US
bordeaux.page102061en_US
bordeaux.volume90en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.institutionBordeaux INP
bordeaux.institutionINRAE
bordeaux.teamNeurogenesis and pathophysiologyen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04785231
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular%20metabolism&rft.date=2024-11&rft.volume=90&rft.spage=102061&rft.epage=102061&rft.eissn=2212-8778&rft.issn=2212-8778&rft.au=HELBLING,%20Jean-Christophe&GINIEIS,%20Rachel&MORTESSAGNE,%20Pierre&RUIZ-GAYO,%20Mariano&BAKOYIANNIS,%20Ioannis&rft.genre=article


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