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dc.rights.licenseopenen_US
dc.contributor.authorBARBEN, Jérémy
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGALVIN, Angeline
dc.contributor.authorKAMGA, Ariane Mamguem
dc.contributor.authorBERTRAND, Nicolas
dc.contributor.authorNIOGRET, Julie
dc.contributor.authorTISSERAND, Julie
dc.contributor.authorQUIPOURT, Valérie
dc.contributor.authorBENGRINE-LEFEVRE, Leila
dc.contributor.authorDABAKUYO-YONLI, Tienhan Sandrine
dc.date.accessioned2024-11-20T12:10:39Z
dc.date.available2024-11-20T12:10:39Z
dc.date.issued2024-11-05
dc.identifier.issn1877-783Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203370
dc.description.abstractEnOvarian cancer (OC) is the eighth most common cancer in women, with a poor prognosis, particularly in older women. The aim of this study was to describe an octogenarian population with OC and to examine the differences in net survival (NS) according to age. In this retrospective observational population-based study from a gynecological cancer registry, patients aged > 18 years with an identified epithelial ovarian cancer stage IA to IVB diagnosed between 1998 and 2018 were included. Patients with non-available FIGO stage were excluded. Patients were stratified into three age groups: <70, 70-79 and ≥80 years, then by OC stage (FIGO I-II, IIIA-IIIB, IIIC-IV). Sociodemographic and cancer-related variables were compared using univariate test (Khi²). The 5-year NS was calculated using the Pohar-Perme method. Among the 721 patients included: 462 (64.1 %) were younger than 70 years, 176 (24.4 %) were aged between 70 and 79 years, and 83 (11.85 %) were aged 80 years or older. Patients ≥80 years had a trend for lower rate of serous carcinoma than the other age subgroups. As age increased, patients were less likely to undergo surgery and chemotherapy. While 73 % of women <70 years received a combination of surgery and chemotherapy, the rate was 62 % among women 70-79 years and 27 % among women ≥80 years (p<.0001). When focusing on FIGO IIIC-IV stages, the 5-year NS rate for women <70 years was 45.1 % (95 % CI 39.1-52.0). For women 70-79 years, it was 25.9 % (95 % CI 18.6-36.1), and for those ≥80 years, it was 19.5 % (95 % CI 10.0-38.0) (p<.005). The oldest patients had less optimal treatment and a lower NS compared to patients in their seventies or younger. Frailty should be carefully assessed to optimize care in the oldest patients with OC.
dc.language.isoENen_US
dc.subject.enOldest old
dc.subject.enOvarian cancer
dc.subject.enSurvival
dc.subject.enTreatment
dc.title.enThe challenge of ovarian cancer care in the oldest old
dc.title.alternativeCancer Epidemiolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.canep.2024.102697en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39505669en_US
bordeaux.journalCancer Epidemiologyen_US
bordeaux.page102697en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04793126
hal.version1
hal.date.transferred2024-11-20T12:10:42Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Cancer%20Epidemiology&amp;rft.date=2024-11-05&amp;rft.spage=102697&amp;rft.epage=102697&amp;rft.eissn=1877-783X&amp;rft.issn=1877-783X&amp;rft.au=BARBEN,%20J%C3%A9r%C3%A9my&amp;GALVIN,%20Angeline&amp;KAMGA,%20Ariane%20Mamguem&amp;BERTRAND,%20Nicolas&amp;NIOGRET,%20Julie&amp;rft.genre=article


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