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Synthesis and self-assembly of branched glycopolypeptides: effect of topology and conformation

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorBONDUELLE, Colin
IDREF: 134527046
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorMAZZAFERRO, Silvia
hal.structure.identifierSch Chem Sci [Dublin City Univ]
dc.contributor.authorHUANG, Jin
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLAMBERT, Olivier
hal.structure.identifierSch Chem Sci [Dublin City Univ]
dc.contributor.authorHEISE, Andreas
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2013
dc.identifier.issn1359-6640
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20334
dc.description.abstractEnBlock copolymers combining peptide and saccharide moieties may play a significant role in future applications of polymers in biology, as they can be viewed as simplified synthetic analogues of glycosylated proteins, which display a wide range of biological functions in nature. While a small number of oligosaccharides containing synthetic polypeptides have been described so far, here we present the efficient preparation of a small library of tree-like glycopolypeptides incorporating poly(gamma-benzyl-L-glutamate) having different molecular weights. A comprehensive study of the self-assembly of these unique grafted macromolecular structures is detailed. All the copolymers presented the ability to spontaneously self-assemble into spherical micelles in water; a property assigned both to the spontaneous curvature of the grafted oligosaccharide segments and to the favorable hydrophilic to hydrophobic volume ratios. These hydrophilic to hydrophobic volume ratios were efficiently counterbalanced by the self-assembly of blends incorporating poly(gamma-benzyl-L-glutamate) homopolymers - this simple approach minimized the influence of the spontaneous curvature of the oligosaccharides' dendrons and afforded a transition to lamellar structures in solution.
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.subject.enAGGREGATION
dc.subject.enARCHITECTURE
dc.subject.enVESICLES
dc.subject.enPOLYMERSOMES
dc.subject.enING-OPENING POLYMERIZATION
dc.subject.enBLOCK-COPOLYMERS
dc.subject.enN-CARBOXYANHYDRIDES
dc.subject.enFACILE SYNTHESIS
dc.subject.enPOLYPEPTIDES
dc.subject.enMICELLES
dc.title.enSynthesis and self-assembly of branched glycopolypeptides: effect of topology and conformation
dc.typeArticle de revue
dc.identifier.doi10.1039/c3fd00082f
dc.subject.halChimie/Polymères
bordeaux.journalFaraday Discussions
bordeaux.page137-150
bordeaux.volume166
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00959599
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00959599v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Faraday%20Discussions&rft.date=2013&rft.volume=166&rft.spage=137-150&rft.epage=137-150&rft.eissn=1359-6640&rft.issn=1359-6640&rft.au=BONDUELLE,%20Colin&MAZZAFERRO,%20Silvia&HUANG,%20Jin&LAMBERT,%20Olivier&HEISE,%20Andreas&rft.genre=article


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