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Exploring strategies to rapidly identify false positives in high-sensitivity cardiac troponin I assay: A prospective study

dc.rights.licenseopenen_US
dc.contributor.authorDESAEGHER, Anthony
dc.contributor.authorMARIN, Victor
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorBEAUVIEUX, Marie-Christine
dc.contributor.authorCOLOMBIÈS, Brigitte
dc.contributor.authorLAUGA, Margaux
dc.contributor.authorALLOUG, Sonia
dc.contributor.authorKALKAN, Selen
dc.contributor.authorCASTAING-MOUHICA, Gladys
dc.contributor.authorLACAPE, Geneviève
dc.contributor.authorRUCHETON, Benoit
dc.contributor.authorDOUBLET, Julien
dc.contributor.authorDABERNAT, Sandrine
dc.contributor.authorBATS, Marie-Lise
dc.date.accessioned2024-11-13T13:50:54Z
dc.date.available2024-11-13T13:50:54Z
dc.date.issued2024-10-11
dc.identifier.issn0009-8981en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203237
dc.description.abstractEnAbstract The evaluation of the efficacy of a drug is a fundamental step in the development of new treatments or in personalized therapeutic strategies and patient management. Ideally, this evaluation should be rapid, possibly in real time, easy to perform and reliable. In addition, it should be associated with as few adverse effects as possible for the patient. In this study, we present a device designed to meet these goals for assessing therapeutic response. This theranostic device is based on the use of magnetic resonance imaging and spectroscopy for the diagnostic aspect and on the application of the convection-enhanced delivery technique for the therapeutic aspect. The miniaturized device is implantable and can be used in vivo in a target tissue. In this study, the device was applied to rodent glioma models with local administration of choline kinase inhibitor and acquisition of magnetic resonance images and spectra at 7 Tesla. The variations in the concentration of key metabolites measured by the device during the administration of the molecules demonstrate the relevance of the approach and the potential of the device.
dc.language.isoENen_US
dc.title.enExploring strategies to rapidly identify false positives in high-sensitivity cardiac troponin I assay: A prospective study
dc.title.alternativeClin Chim Actaen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.cca.2024.119996en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.identifier.pubmed39396631en_US
bordeaux.journalClinica Chimica Actaen_US
bordeaux.page119996en_US
bordeaux.volume565en_US
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04765936
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinica%20Chimica%20Acta&rft.date=2024-10-11&rft.volume=565&rft.issue=1&rft.spage=119996&rft.epage=119996&rft.eissn=0009-8981&rft.issn=0009-8981&rft.au=DESAEGHER,%20Anthony&MARIN,%20Victor&BEAUVIEUX,%20Marie-Christine&COLOMBI%C3%88S,%20Brigitte&LAUGA,%20Margaux&rft.genre=article


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